Endocrine Abstracts

IntroductionMultiple Endocrine Neoplasia type-1 (MEN-1) is an inherited autosomal dominant condition with a high degree of penetrance characterized by tumour occurrence in the form of pancreatic neuroendocrine (pNET), parathyroid and anterior pituitary gland tumours, among others. Treatment for MEN-1 associated endocrine tumour, particularly pancreatic, is more challenging than in those without MEN-1, given its multicentric nature and aggressive behaviou...

Giant prolactinomas are rare tumours, accounting for only 2–3% of all prolactin (PRL)-secreting tumours which can pose therapeutic challenges. It has a higher preponderance in men with a male to female ratio of about 9:1. A 70year old gentleman initially presented to the ophthalmology department with blurred and reduced colour vision. He denied any headache, galactorrhoea or gynaecomastia however he noticed reduced libido and difficulties with erections. His past medical ...

Background: Malignant hypercalcemia (MH) occurs in up to 30% of patients who are diagnosed with cancery, being associated with later stages of the disease and poor prognosis. The physiopathological mechanisms responsible for MH are the production of parathyroid hormone-related peptide by the tumor (PTHrp) (80% of cases), osteolytic cytokine production (20%) and excess of 1,25(OH)2vitamin D production (1%).Case report: We present the case of a ...

Background: World Gastroenterology Organisation (WGO) quotes gallstones prevalence of 9-21%, incidence of 0.63/100 persons/year in Europe; 10-15% of UK population have gallstones (1). Acromegaly patients’ prevalence is 8.3% and 35% developing incidental gallstones during somatostatin analogue (SSA) treatment (2).Objective: To evaluate the prevalence of gallstones in SSA treated Acromegaly patients in University Hospitals of Leicester (UHL).<p cl...

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million habitants/year, often with a dismal prognosis. Patients present with abdominal symptoms or symptoms of hormone excess. However, 15% are diagnosed incidentally. (1) A 59y male was referred with progressive lethargy, weight loss, dyspepsia and abdominal distension over the past 2 years. He was dismissive of ‘the elephant in the room’ and in denial. He was pushed to seek ...

We present two patients with an unusual cause of primary hyperparathyroidism.A 50 year old man was referred due to incidentally noted raised serum calcium consistent with primary hyperparathyroidism (adjusted calcium 3.52 mmol/L, phosphate 0.66 mmol/L, PTH (parathyroid hormone) 99.5 pmol/L, Vitamin D 46 nmol/L). An initial neck ultrasound demonstrated a 1.2x1.7 cm left sided presumed parathyroid nodule but also a cystic 3.3x3.2x1.7...

We present two patients with an unusual cause of primary hyperparathyroidism.A 50 year old man was referred due to incidentally noted raised serum calcium consistent with primary hyperparathyroidism (adjusted calcium 3.52 mmol/L, phosphate 0.66 mmol/L, PTH (parathyroid hormone) 99.5 pmol/L, Vitamin D 46 nmol/L). An initial neck ultrasound demonstrated a 1.2x1.7 cm left sided presumed parathyroid nodule but also a cystic 3.3x3.2x1.7...

Acromegaly is a relatively rare disorder with a prevalence of 40 per million. Diagnostic and management process have evolved with time, however lack of statistical facts/data remained an issue.Aims: 1) To look at the cohort of patients who attend our local Endocrine department with a diagnosis of acromegaly. 2) To determine how many are cured with surgery, how many need adjuvant treatment and how many remain uncontrolled despite all treatment modalities....

IntroductionPrevious studies in women with idiopathic infertility have shown that obesity does not independently contribute to the decrease in the success of assisted reproductive technology (ART) techniques. However, few studies evaluated the success rate of ART between obese and non-obese women in infertility associated with PCOS.ObjectiveTo compare the number of oocytes, mature oocytes, number of embryos a...

A 65 years old male chef presented with a history of weight loss of 15kg over a 12-month period associated with lethargy, constipation and abdominal pain. His past medical history included epilepsy, hypertension and gastric reflux. He reported no family history of endocrinopathies.At presentation his performance status was 0 and was found to have hepatomegaly. In view of rapid weight loss and hepatomegaly he had a CT scan of the abdomen and pelvis, which showed multiple hyperv...