Endocrine Abstracts

Introduction: Although numerous noninvasive markers are being used in order to determine preoperative thyroid cancer risk in patients with multi-nodular goiter, none of them are optimal. The objective of this study was to compare retrospectively the TSH level between two groups of subjects who underwent total thyroidectomy for a nodule and whose final histology was benign or malignant.Methods: Our study included 208 patients that underwent thyroidectomy ...

Background: The main objective of this study is to establish the rate of malignancy in residual thyroid tissue in patients with DTC, and whether the serum thyroglobulin (Tg) level before complementary thyroidectomy and histopathologic characteristics of the tumor would be able to foresee malignancy in residual tissue.Methods: Our study included 58 patients with DTC that underwent complementary thyroidectomy that results were analyzed retrospectively. Pat...

The recent unavailability of pentagastrin (Pg) in several European Countries, prompted us to evaluate the potency and tolerability of the ‘high dose calcium test’ (Ca) in the stimulation of serum human calcitonin (hCt). We compared Pg- and Ca-stimulated hCt in 19 patients already treated for medullary thyroid cancer (MTC) in remission (n=19) or in persistence (n=13), in 18 patients with chronic thyroiditis and multinodular goiter, and in 15 healthy cont...

Introduction: Two identically designed randomized, placebo-controlled double-blind studies (one conducted in North America and the other one in Europe and Australia) showed that an oral contraceptive containing estradiol valerate (E2V)/dienogest (DNG) in an estrogen step-down, progestogen step-up 28-day regimen was effective in women with heavy and/or prolonged menstrual bleeding without organic pathology. Both studies applied a strict definition of treatment succes...

Brown adipose tissue (BAT) is an insulin sensitive organ having a very high uptake of glucose per gram of tissue. The role of insulin on glucose uptake in BAT is still poorly understood, moreover, it is not clear whether BAT insulin function is compromised with obesity. We used a small animal PET/CT imaging approach to analyse insulin function in vivo in lean and obese mice using a glucose analogue PET tracer (18F-FDG). Three groups of mice were analysed afte...

Evidences have suggested that the endocannabinoid system is overactive in obesity, resulting in enhanced endocannabinoid levels in both circulation and visceral adipose tissue. The cannabinoid CB1 receptor is expressed in the adipose tissue besides the brain. Few studies in vitro suggest that CB1 activation increases glucose uptake in adipocytes. The objective of the present study was to investigate the CB1 receptor modulation on glucose transporter GLUT4 expression, which is ...

Introduction: Insulin resistance results from a combination of genetic and environmental factors and it may be considered the primary cause of the development of metabolic disorders, such as type 2 diabetes mellitus. It is characterized by a reduced ability of insulin sensitivity tissues to respond to normal levels of the hormone. In these tissues, glucose transport stimulated by insulin occurs through the glucose transporter 4 and alterations in its expression are related to ...

Introduction: To evaluate if improved thyroid status in patients with hypopituitarism would improve cardiovascular risk markers.Patients and methods: A total of 85 hypopituitary patients (45 women) with GH deficiency; 7 had isolated GH deficiency, 25, 16 and 22 patients had 1, 2 and 3 additional deficits respectively. Fifteen patients had panhypopituitarism. Biochemical and body composition assessment was performed at baseline (when patients were GH na&#...

Background: Previous nation-wide survey on iodine deficiency disorders (IDD) in Latvia showed a mild iodine deficiency in 587 schoolchildren (median UI – 59 μg/l). At the time less than 1% of all edible salt was iodized. Despite of the results of National IDD Elimination Committee study, all preventive measures were limited to production of leaflets promoting voluntary iodine salt consumption and convincing industry to use iodized salt. In order to perform a 10-year ...

Introduction: Thyrotropinomas are rare pituitary tumour accounting for 0.5–1.0% of all pituitary tumours. There are only seven reported cases of mixed TSH/LH/FSH producing adenoma. We report a patient with secondary hyperthyroidism due to TSH producing adenoma co-secreting FSH and LH.Case report: A 75-year-old Caucasian male was seen with 2-year history of tiredness, anxiety and palpitations along with 7-month history of weight loss. He also complai...