Endocrine Abstracts

An 18 year old nursery nurse suffered two probable seizures. She was commenced on Phenytoin. She had had a cleft palate repair. Clinical examination revealed hypertelorism and short fourth metatarsals. Early papilloedema was noted. Routine blood tests showed profound hypocalcaemia of 1.2 mmol/l. Serum phosphate , magnesium and parathormone levels were normal. She suffered a further seizure and was given intravenous calcium. She suffered no further seizures and calcium levels w...

A 36-year-old lady presented at 26-weeks gestation with symptoms of palpitations, anxiety, tremors, and breathlessness. She had received the 1st dose of the mRNA vaccine (Pfizer) for Covid-19 a month prior and her symptoms started a couple of weeks after the vaccine. She was a gravida 4 para 2 with gestational diabetes diagnosed during previous pregnancies and also early on in the current pregnancy requiring insulin treatment maintaining excellent antenatal glycaemic control. ...

Introduction: Thyrotoxicosis is a common condition referred to endocrine clinics. However, not all of them needed treatment with antithyroid medications. We report a case of thyroid hormone resistance due to a novel TSHRβ mutation who has been treated with subtotal thyroidectomy and antithyroid medications due to raised T4 levels.Case report: A 38-year-old south Asian woman was seen in orthopaedic clinic for elective right foot scarf oste...

Background: Headache often occurs as incapacitating symptom among the patients with acromegaly. GH involvement in the pathophysiologic mechanism and an analgesic effect of somatostatin analogues has been described, but the exact mechanism is not clear. Whether the pan somatostatine (sst)-receptor agonists are superior as concern the antinociceptive effect than the more selective ones is not evidenced.Case report: A 21-year old woman, diagnosed with acrom...

Aim: To study character of neuroendocrine disorders in children and adolescents with the Turkish saddle volume formations.Materials and methods: we examined 35 children and adolescents, 17 girls and 18 boys among them with the Turkish saddle volume formations at the neuroendocrine department of the Center for the scientific and clinical study of endocrinology. All examinees underwent general clinical examination as well as biochemical and hormonal invest...

Objective: To evaluate the association between body-composition and peak GH, during two standard GH stimulation tests; the pyridostigmine-GHRH (PDGHRH) test and an insulin tolerance test (ITT).Method: 83 healthy subjects (56 men), aged 18–65 years with a median BMI of 24 kg/m2 (range 17–35) underwent a PDGHRH test and an ITT in random order 1 week to 1 month apart. Women had both tests performed in the same phase of their menstrual c...

Alterations in thyroid hormone levels are commonly observed in critical illness with thyroxine replacement remaining a controversial issue. We undertook a prospective observational cohort study in medical intensive care unit of Gauhati Medical College to evaluate whether thyroid hormone levels at admission could be used to predict mortality and compared it to the well established APACHE II scoring system for ICU patients. Serum T3, T4 and TSH were estimat...

Aim: To study clinical presentation peculiarities of constitutional puberty delay in boys.Materials and methods: We examined 54 boys (mean age 13.8 years) with constitutional puberty delay (CPD). All examinees underwent general clinical examination as well as biochemical and hormonal investigations (levels of GH, LH, FSH, free testosterone, prolactin, cortisol, TSH, etc.), having their bone age and anthropometric parameters by Tanner-Whitehouse measured ...

Aim: To study significance of risk factors in puberty delay in boys.Materials and methods: We examined 54 boys (mean age 13.8 years) with constitutional puberty delay (CPD). All examinees underwent general clinical examination as well as biochemical and hormonal investigations (levels of GH, LH, FSH, free testosterone, prolactin, cortisol, TSH, etc.), having their bone age and anthropometric parameters by Tanner-Whitehouse measured and their sexual devel...

Introduction: The understanding and approach to management of DSDs has undergone rapid changes in recent years with focus on early diagnosis followed by disclosure and decision making with family members. However in certain regions specially in developing countries, lack of awareness and the social environment contribute to late diagnosis and problems in management. The present study was done to assess the clinical presentation of DSDs attending an endocrine clinic at a tertia...