Endocrine Abstracts

Introduction: Subclinical hypercortisolism (SH), affecting about 30% of patients with unilateral adrenal incidentaloma (UAI), has been associated to hypertension (HT), type 2 diabetes mellitus (T2DM), dyslipidemia (DL), osteoporosis and vertebral fractures (FX). The prevalence of SH in patients with bilateral adrenal incidentaloma (BAI) seems to be even higher. Data on metabolic and bone complications in these patients are lacking.Methods/design: We enro...

Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, ...

The effects in vitro and in vivo of somatostatin (SS) analogues are linked to the presence of specific binding sites on target cells. Estradiol (E2) may modulate the expression of SS receptors (SSTR) in some cell models, including breast cancer and pituitary cells. Aim of this study was to evaluate the effects of E2 on SSTR1-5 ligand binding domains (LBD) expression levels in prostate epithelial cells (PEC).Methods: We investigated the effe...

Objective: There is a complex cross-talk between bone and glucose metabolism. The surrogate markers of bone metabolism are osteocalcin (for bone formation) and CTx (for bone resorption). The osteoblast-derived protein osteocalcin has recently been shown to affect glucose homeostasis.Aim of the study: To investigate the relationship between markers of bone metabolism and parameters reflecting bone composition, glucose homeostasis and insulin resistance in...

Introduction: Hypothalamo-pituitary dysfunction has been reported in patients after traumatic brain injury or subarachnoid hemorrhage with relatively high frequency according to published studies. Assessment of hypothalamo– pituitary functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo- pituitary unit could be expected (head trauma, compression and oedema of the brain, shifting of the midline structures).</p...

Testosterone (T) can induce SSC in young HH men. So far the T ester formulations have been used for inducing puberty in these patients. Moreover, it seems that the polymorphism CAG length of androgen receptor (AR-CAG) might co-regulate the effectiveness of testosterone therapy (Tth).This study aims to evaluate the effectiveness of Nebid (1000 mg) for SSC induction in HH men and, secondly, whether these changes might be modulated by the AR-CAG.<p clas...

Context: Initial studies reported that RET rearrangements, RAS mutations and BRAF mutation are mutually exclusive genetic events in papillary thyroid carcinoma (PTC). Subsequently, simultaneous occurrence of BRAF mutation and RET/PTC or H4-PTEN has been described in few PTC cases, indicating that these genetic alterations might coexist in PTC in the same cell or in different cells, at least sporadically. In light of the recent finding that frequently BRAF mutation is present o...

Liver X receptors (LXRalfa and LXRalfa) act on the cholesterol homeostasis in several tissues, including adrenals. In particular, LXRalfa regulates the expression of several genes involved in the cholesterol efflux and storage and modulates glucocorticoid synthesis in mice. The level of the expression of LXRs in the human adrenal adenomas is unknown. We evaluated LXRalfa and LXRbeta mRNA levels in cortisol-secreting adenomas (CSA) and in the surrounding normal tissue, obtained...

The gypsy moth, Lymantria dispar L., is one of the most destructive phytophagous pests of the northern hemisphere. It shows a tremendous capacity to increase in numbers, and feeds on a wide range of trees and shrubs. However, several different systems driving feeding behavior and digestion of Lymantria dispar L. have not yet been elucidated.Ghrelin along with several other hormones has significant effects on appetite and growth in humans an...

Aim: To compare gender frequency of leptin receptor gene (LEPR) genotype rates and leptinemia levels in overweight children.Materials and methods: Three hundred children with adiposity were investigated (divided into groups: prepubertal (1st) m/f n=51/50, early pubertal (2nd) n=49/51, late pubertal (3d) n=50/49). 80 girls and 89 boys with obesity and 90 lean girls and 48 lean boys (control) were genotyped in 6 exon of LEPR gene (Q223...