Endocrine Abstracts

Diagnosis of hypoglycaemia presents few difficulties nowadays providing it is (a) thought of and (b) appropriate samples of blood are collected whilst the patient is hypoglycaemic for subsequent analysis in a suitable laboratory. Adherence by the laboratory to well defined protocol that will be presented and commences with confirmation that the glucose concentration in the plasma/serum specimen submitted for analysis is truly subnormal, will usually resolve the diagnostic dile...

Back ground: The reported prevalence of microalbuminuria (MA) range from 9% to 54%. Diabetics in these studies were hypertensive and were on different medications which could influence results. Aim: To know the prevalence of MA in diabetics not on antihypertensive medication, normal serum creatinine, no overt proteinuria and were also not on statins. Methods: The data were collected from the Diabetes Register of patients at annual check up at Hartlepool General Hospital. Durin...

Adiposity is a major risk factor for insulin resistance and type 2 diabetes. PPAR gamma, an orphan nuclear receptor, is highly expressed in adipose tissue. Paradoxically, synthetic PPAR gamma ligands including thiazolidinedones (TZDs), which activate PPAR gamma induce adipogenesis yet improve insulin sensitivity. We have shown that TZDs selectively induce human subcutaneous but not omental preadipocyte differentiation in vitro, correlating with the observation that trea...

Introduction: Despite advances in analytic and imaging techniques, the syndrome of ectopic ACTH secretion from a tumour resulting in Cushing’s syndrome continues to pose difficult diagnostic and therapeutic challenges. We report a patient with ectopic ACTH from a bronchial carcinoid tumour highlighting the unusual presentation and difficulties in management.Case description: A 23-year-old man with a past medical history of Cushing disease presented ...

Rajesh Thakker is the May Professor of Medicine at the University of Oxford, UK. He received his medical degree from the University of Cambridge in 1980, and from 1981 to 1988 he undertook postgraduate clinical and research training at The Middlesex Hospital, The Hammersmith (Royal Postgraduate Medical School, RPMS), Hospital, and Northwick Park (MRC Clinical Research Centre) Hospital (London). In 1988, he was appoint...

Ablative radioiodine therapy is critical to the treatment of differentiated thyroid cancers and their metastases, and relies on the innate ability of thyroid cells to uptake iodide via the sodium iodide symporter (NIS). As tumours with reduced avidity for radioiodine have a poorer prognosis,it is critical to identify ways to induce NIS activity and hence radioiodine uptake.Pituitary tumor transforming gene (PTTG) and its interacting partner, PTTG-binding...

Introduction: Diabetic polyneuropathy is detected in 12.5–14.5% of patients after 5 years of falling ill.Aim: To detect predictors of diabetic polyneuropathy development in prospective parallel open clinical research.Methods: From 2010 to 2012, 189 patients were examined (108 men, 81 women, average age – 38±7 years) with DM type 2 (82%) and type 1 (18%), without neurological complaints. We estimated the neurological ...

This is the review of original data concerning the role of some metabolic hormones (GH, leptin, ghrelin, obestatin), growth factors (IGF-I, IGFBPs, EGF, thrombopoietin), intracellular mediators of their action (cyclic nucleotides, protein kinases, PKA, MAPK, CDK, transcription factors, CREB, STAT-1, p53 and related cDNA, siRNA and miRNA gene constructs) on basic ovarian functions (cell proliferation, apoptosis, secretion, oogenesis, ovulation, production and viability of pups)...

The aim of the research was studying the influence of age and sex on the changes of bone mineral density detected on rats with experimental hyperthyroidism.Research object: Research is conducted on 180 white females and males rats of ‘Wistar’ breed. Animals were arranged in the 12 groups: six controls groups (CG) of pre-pubertal, reproductive and old males and females; six age-dependent groups of males and females rats getting L-...

The aim of this study is evaluating body composition in postmenopausal women depending on presence of vertebral fractures in their anamnesis.Materials and methods: We’ve examined 144 postmenopausal women aged 50–83 years (mean age – 62.9±0.7 years; mean height – 160.6±0.5 cm; mean weight – 71.9±1.2 kg). The patients were divided into two groups: group A – women without vertebral fractures (n=82), group ...