Endocrine Abstracts

Retrospective data collection was performed for all of the paediatric vitamin D (25-hydroxycolecalciferol) serum samples analysed over the preceding 13 months. Around 300 requests were made for vitamin D sampling by various medical professionals including paediatricians (72%), general practitioners (13%), and orthopaedic surgeons (16%). 231 samples, costing £9 per sample, were analysed on 200 patients, predominantly for clinical indications such as growing pains, tubercul...

Materials and methods: We investigated 79 normal (1st group) and 99 overweight (2nd group) preschool children. Deficient sport and average physical activity (APA) duration, risen appetite (point-assessment), prolonged television viewing and computer using time in children were considered as risk-factors of juvenile obesity manifestation. Height, weight, waist circumflex (WC) was measured; body mass index (BMI) was calculated. Serum leptin levels were detected by immunoenzyme m...

We evaluate the short and long-term outcomes following diagnosis and treatment of pituitary dependent Cushing’s disease from a single centre. From 1971, there were 47 patients with proven endogenous cortisol excess, of whom, 43 (92%) had pituitary dependent Cushing’s disease. The median age of this cohort was 38±11years and the majority (77%) were females. 17 patients had primary treatment either with radiotherapy (n=9), bilateral adrenalectomy (n=...

Background:Long acting somatostatin analogues are an effective treatment for acromegaly but require administration by nurses.To improve patient convenience we have taken care into the community with endocrine specialist nurse education of practice nurses in administration of injections.Methods:After an initial pilot study, a questionnaire was administered to patients receiving, and practice nurses administering, Somatuline Autogel(SA) n=10 and Sandostati...

Aim: To ascertain the types of treatment, results and correlation between GH and the simultaneous IGF-1. Setting: Endocrine and Neurosurgical Unit. Methods: Endocrine and laboratory database of 17 acromegalic patients (11 male) with mean (SD) age 51(3) years and follow up 11 years. Results: Pituitary surgery 11 patients (3 twice), external radiotherapy 10 (one heavy particle therapy). GH levels have come down from a median value 32.5 mU per litre (Mean plus/minus SEM: 51.9 plu...

Introduction: Medullary thyroid cancer (MTC), in its familial forms, is usually associated with pheochromocytoma and primary hyperparathyroidism, related to an underlying germline RET mutation. SDHx germline mutations associated with MTC have not yet been reported.Case report: We report the case of a 60-years-old woman, who was submitted, elsewhere, in November/2013, to a total thyroidectomy+right lymph-node dissection due to a nodule s...

Introduction: Anaplastic thyroid carcinoma (ATC) is characterized by an aggressive clinical course and refractoriness to currently available local and systemic modalities of treatment. It is considered the most aggressive solid tumor, with few patients alive more than 1 year following diagnosis.Bible et al have reported a combined therapy of radiation and radiosensitizing adjuvant chemotherapy, with some positive results.Case repor...

Aim: Management of type 1 diabetes in children is a complex process. Active participation of the child and family in diabetes care is essential for achieving good glycaemic control. A good parental understanding of diabetes and its management would be considered a prerequisite for their involvement in the care of their children’s diabetes. The aim of this study was to explore the relationship between parental knowledge of diabetes self management and glycaemic control of ...

We present 2 patients who developed severe thyrotoxic exacerbation following radioiodine. The first treated by conventional antithyroid therapy, the second was plasma exchanged.Patient A aged 39 male with FT3=28.2 pmol/l (2.5–5.3) FT4=49.0 pmol/l (9.1–23.8) TSH=<0.01 mU/l (0.32–5.0),a large diffuse goitre, thyroid eye disease and asthmatic on inhaled ventolin. He received 3.5 years of carbimazole 40 mg and thyroxine 100 mcg. Thyroxine ...

Background and objectiveHyponatraemia is a common metabolic disorder with a significant morbidity and mortality, especially in the elderly. However, its significance is often ignored, and when found, inadequately investigated and inappropriately managed. The objectives of this audit were to investigate the investigations and management of hyponatraemia in a large District General Hospital.MethodsFrom the bioc...