Endocrine Abstracts

We use redundant peptide counting as a tool to compare, quantitatively, data from mass spectrometry analyses. When combined with hierarchical clustering, a tool commonly used for micro array analysis, we can group proteins based on their relative abundance across samples. In this way, we recently completed a spatial map of the secretory pathway of rat hepatic cells comprising some 1400 different proteins, each with a defined distribution (Gilchrist, Au, Hiding et al. 20...

The highly conserved Leptin-Melanocortin signaling pathway plays a central role in the regulation of body weight and energy expenditure. Mutations in POMC and MC-4R lead to dosage dependent monogenetic obesity. However, several evidences suggest an epigenetic impact on the regulation of body weight. Moreover it has been shown recently that variants of the FTO gene, which affects ss DNA methylation in the arcuate nucleus, correlate with increased body weight in children and adu...

Somatostatin (somatotrophin release inhibiting factor; SRIF) is produced primarily in the hypothalamus and pancreas and inhibits the secretion of many hormones and neurotransmitters. Moreover, SRIF and SRIF analogs are able to inhibit tumor growth. Many human neuroendocrine and non-neuroendocrine tumors express the five known somatostatin receptors (sst1–5) in different amounts.Tachyphylaxis after prolonged treatment with octreotide (Sand...

Background: 1,25-dihydroxy vitamin D mediated hypercalcemia resulting from an inflammatory reaction caused by a foreign body such as a textiloma has never been described.Clinical case: A 61 year-old man with a medical history of Alport syndrome and in need of chronic dialysis after transplant kidney resection because of relapsing severe urinary tract infections, presented with recurrent and progressive hypercalcemia two years after parathyroidectomy (C a...

Introduction: Diagnosis and treatment of neurosarcoidosis (NS) can be challenging. We describe an unsual presentation of an isolated NS in a 21 year old adult, initially presenting with central diabetes insipidus (DI) associated with a stalk thickening at the age of 14.Case description: A 21 year old patient was first seen at the department of endocrinology after a 9 years follow-up for panhypopituitarism. He presented at the age of 14 years at the pedia...

IntroductionRecently, cross-sectional studies report associations between long-term glucocorticoid levels in scalp hair (HairGC) and obesity. However, there is a wide variation in studied outcomes and associations, possibly caused by differences in population characteristics, e.g. age, sex, dispersion of adiposity, and used laboratory methods. The aim of this systematic review and meta-analysis was to investigate the relation between HairGC and anthropom...

Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha (RTHα) is a syndrome whose features include delayed growth and neurocognitive development. Macrophages, which derive from circulating monocytes and have recently been recognized as important thyroid hormone target cells, are innate immune cells that are capable of adopting a wide range of phenotypes. Assuming the right phenotype in the right setting is crucial as macrophage dysfunction has b...

Purpose: Deficiency of the adrenocortical axis is, except for glucocorticoid-induced adrenal deficiency, most commonly associated with failure of multiple pituitary axes and is less common isolated. Isolated adrenocorticotropic hormone deficiency (IAD) has been first described by Steinberg et al. in 1954. Acquired idiopathic IAD is defined by a secondary adrenal insufficiency with otherwise normal pituitary function, absence of structural pituitary defects, no...

Background: Over the last two decades, type 2 diabetes mellitus (T2DM) has increasingly been recognized as a fracture risk factor, despite the occurrence of normal to even increased bone mineral density (BMD) (1). The dual energy X-ray absorptiometry (DXA) derived trabecular bone score (TBS) is considered to be a proxy of bone quality and has been reported to be diminished in diabetic patients (2) and insulin resistant, non-diabetic postmenopausal women (3).</...

Introduction: Patients with prolactinomas suffer from a wide range of symptoms, of which the effect on health-related quality of life (HR-QoL) needs further investigation. Moreover, the first-line treatment for patients with prolactinomas, dopamine agonists (DAs), albeit being effective in lowering prolactin levels, might further hamper HR-QoL due to side effects. To assess the impact of symptoms and treatment modality on HR-QoL, a cohort of patients with prolactinoma was cros...