Endocrine Abstracts

In vitro 3D cell culture systems seem to appropriately reproduce the tumor cell microenvironment, including nutrients-oxygen conditions and cell-cell interactions. These models may better mimic in vivo tumor conditions and more accurately reproduce drug treatments effects. Since most in vitro studies in neuroendocrine tumors (NETs) are performed in 2D culture systems (monolayer), we aimed to compare the monolayer system with a 3D spheroid cell cultur...

Introduction: Craniopharyngiomas are benign tumors in the suprasellar region that have encouraging survival rates between 77-93%. Unfortunately, long-term sequelae are frequent, resulting in excessive endocrine and metabolic morbidity, including premature cardiovascular disease and reduced bone health.Objective: To determine the prevalence of unfavorable body composition and low bone mineral density (BMD) in patients with craniopharyngioma.<p class="...

BackgroundPrecise diagnostics for postprandial reactive hypoglycaemic syndrome (PRHS) after gastric bypass surgery (GBS) are lacking. Oral glucose tolerance tests are advocated but might cause early dumping in this population and often cause hypoglycaemic values in a normal population.AimTo evaluate glycaemic responses during liquid and solid mixed meal tolerance tests (LMMTT and SMMTT) in a post-GBS populati...

IntroductionPrader-Willi syndrome (PWS) is a complex genetic syndrome in which hypothalamic dysfunction leads to hyperphagia and pituitary hormone deficiencies (PHD), among others. The majority of patients have intellectual disability (ID) and use of psychotropic drugs is frequent. Due to hypotonia and the low muscle mass associated with the syndrome, adults with PWS have a low basal metabolic rate (BMR). Combined with hyperphagia, this results in high r...

Background: Differentiated thyroid carcinoma (DTC) survivors have an increased risk of cardiovascular mortality but, the pathophysiological mechanism remains largely unknown. Early treatment for high-risk DTC entails thyroid surgery, radioiodine therapy with thyroid hormone (TH)-withdrawal, and thyroxine suppression therapy (THST). During treatment, patients cycle from severe hypothyroidism to exogenous subclinical hyperthyroidism. TH changes in early DTC treatment might affec...

Introduction: Historically, treatment of follicular thyroid carcinoma (FTC) and oncocytic thyroid carcinoma (OTC) is based on thyroidectomy followed by radioiodine (RAI) therapy. Both tumor types have a good prognosis (10-year survival 80-94%), but this changes significantly once RAI-refractory disease occurs (median 3.5 years), which limits further treatment possibilities. The main risk factors for developing RAI-refractory disease in FTC and OTC are unknown. Our aim was to i...

Purpose : To assess the utility of (18F)fluoroethyl-L-tyrosine PET co-registered with magnetic resonance imaging (FET-PET/MRICR) in patients with difficult-to-localize prolactinoma to inform clinical decision making and treatment planning.Methods: Retrospective cohort study of 17 consecutive patients with difficult-to-localize prolactinoma undergoing FET-PET/MRICR between October 2020 and Amgust 2022 for either (1) additional inform...

Background: Patients with acromegaly without detectable pituitary adenoma on conventional MRI are often excluded from adenomectomy due to inherent challenges of precise surgical planning, significantly limiting both their therapeutic options and chances of curation. Previous research showed that O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) PET-MRI is an accurate diagnostic tool to detect small functional pituitary adenomas (1). The present study aims to investigate the diagnos...

Introduction: To prevent ovarian cancer, BRCA1/2 germline pathogenic variant carriers are recommended to undergo premenopausal risk-reducing salpingo-oophorectomy (RRSO). Premenopausal RRSO leads to immediate surgical menopause, which has been associated with an acute phase of rapid bone loss. However, data on long-term effects is scarce and inconclusive. Therefore, we investigated the long-term impact of premenopausal RRSO on bone mineral density (BMD).<p class="...

Background: Familial renal glucosuria (FRG) is a rare renal tubular disorder characterized by increased urinary glucose excretion despite normoglycemia. The sodium-glucose cotransporter 2 (SGLT2) is expressed in the proximal renal tubule and is crucial for glucose reabsorption. SLC5A2 is a member of the solute carrier family V transporter genes and encodes for this cotransporter. Mutations in SLC5A2 are the primary cause of FRG.Case pre...