Endocrine Abstracts

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers (FTC). However, patients with incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit worse prognosis. Therefore, a novel and effective treatment is...

Introduction: Patients with mitochondrial disease have abnormal cellular adenosine triphosphate (ATP) generation that results in a broad phenotype with a diverse clinical presentation. Abnormal growth and short stature have been observed in children and adults with mitochondrial disease and we hypothesized that stature in affected individuals would reflect disease severity.Method: We extracted height, weight and molecular genetic data from the UK Mitocho...

Objective: Hyperprolactinemia might be related to weight gain, metabolic syndrome, and insulin resistance. The aim of this study was to evaluate that patients with hyperprolactinemia were higher prevalence of metabolic syndrome than civilian population.Methods: From 1st Jan. 1998 to 17th Nov. 2017, 950 patients newly diagnosed hyperprolactinemia in Pusan National University Hospital, Pusan, South Korea, were selected to enroll in a study conducted on hyp...

Recent statistics indicate that prostate cancer (PC) is the most frequent cancer in men worldwide and is the leading cause of cancer death in men above 50 years of age. The Androgen receptor (AR), a member of the superfamily of nuclear hormone receptors, plays a well-established role in the development and progression of the disease. PC localized to the prostate is commonly treated with surgical removal of the gland and is often associated with a favorable outcome. However, me...

Background: Stress induced hyperglycemia is common during acute illness and is related to poorer clinical outcome.Objective: To evaluate the correlation between plasma glucose elevation from baseline and clinical outcome during acute illness.Design: Retrospective, observational cohort of patients presenting to emergency department with plasma glucose concentration >500 mg/dl.Participants: 661 patients vis...

Increasing evidence indicates chronic stress plays an important role in a variety of health problems such as the development of autoimmune disease, and the results from mice studies suggest that the central endocannabinoid (eCB) system regulates endocrine and neuronal responses to stress. However, it is unclear how the eCB system responds to chronic stress in healthy humans. A 520-day isolation-and-confinement study simulating an interplanetary spaceflight mission to Mars prov...

Fenhexamid is one of antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. Fenhexamid has been reported to act as an anti-androgen in an androgen receptor reporter assay in engineered human breast cancer cells. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which translocates into nucleus and dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). Although function of AR...

The class of endocrine disrupting chemicals (EDCs) is comprised of both naturally occurring and man-made compounds which are structurally similar or distinct to estrogen, and can interfere with the actions of an endogenous steroid hormone via estrogen receptors (ERs). Octylphenol (OP) is alkyl phenol chemical, which is considered to be a low-level endocrine disruptor owing to its tendency to mimic estrogen. It has been reported that triclosan can cause endocrine disruption and...

Endocrine disrupting chemicals (EDCs) have brougt the growing concern about the potential to interfere with the endocrine system and to cause health problems. Among EDCs, bisphenol A (BPA) and 1,1,1-trichloro-2,2-bis(4-methoxyphenol)-ethane (methoxychlor, MXC) can bind to estrogen receptors (ERs) and lead abnormality of ER depenent signaling pathways, resulting in human health problems such as dysfuction of reproduction and carcinogenesis. In this study, we investigated whethe...

Hyperuricemia, results from the disorder of purine metabolism or endocrine system, leads to an inflammatory arthritis and gout. Sesame oil has been reported to have a potent anti-inflammatory effect in various animal models. The aim of the present study is to examine the therapeutic effect of sesame oil on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in air pouch in unanaesthetised Sprague–Dawley rats. Air pouch, a commonly used model for gouty ar...