Endocrine Abstracts

Lactation is under the control of the anterior and posterior pituitary via prolactin and oxytocin release. A number of galactogogues, including dopamine antagonists, have been described and used with success in lactation induction. To date, there are no reports in the literature of their use in patients with panhypopituitarism. We present the case of a forty-year-old female known to endocrinology services with a background of anterior panhypopituitarism and AVP deficiency asso...

Background: In November 2017, a nurse-led Adrenal Incidentaloma (AI) clinic was launched at the University Hospital of Wales (UHW), Cardiff, based upon the 2016 European Society of Endocrinology AI management guidelines.Objectives: To evaluate the effectiveness of a nurse-led clinic in managing AI patients at UHW.Methods: Retrospective analysis of electronic records of patients see...

Decamethylcyclopentasiloxane (D5) is one of the most common chemical ingredients for daily necessities that can be absorbed through the skin, aerosol, or even orally. People are exposed to D5 daily, but the risk of prenatal exposure to D5 is not completely understood. In this study, the effects of prenatal exposure to D5 on neural development were assessed through behavioral tests on offspring mice. First, the developmental neurotoxicity test (DNT) was performed to determine i...

Backgrounds: Based on anthropometry and blood biochemical tests, this study aims to analyze the variation of glucose and lipid metabolism in Cushing’s syndrome (CS) patients caused by adrenal adenoma combining with flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA).Methods: According to the strict diagnostic and exclusion criteria, seven healthy controls (HCs) and seven CS patients were collected in this study. First,...

The pentose phosphate pathway (PPP) plays an important role in the biosynthesis of ribonucleotide precursor ribose-5-phosphate and NADPH. Glycolytic reprogramming of cancer cells frequently involves dysregulation of PPP flux. A previous study suggested that the expression of transketolase like 1 (TKTL1) was associated with invasiveness of papillary thyroid cancer. In the present study, we found that the combination of G6PD and transketolase inhibitors exerted a synergic effect...

Introduction: This audit was undertaken to determine whether Primary Hyperparathyroidism (PHPT) management in the clinical setting is compliant with the nine standards set of the existing PHPT pathway in the City Hospital Sunderland Foundation Trust (CHSFT). PHPT pathway was developed in (CHSFT) to allow effective management and surgical referral for this common condition in line with available national and international guidelines.Methods: Data was retr...

Objective: We longitudinally assessed the overall and age- and sex-specific incidence rates and relative risks of newly diagnosed diabetes mellitus in patients surviving the first-attack acute pancreatitis (AP) as compared to matched controls.Methods: Study cohort included 2966 AP patients and 11 864 non-AP controls individually matched on age, sex and date of index admission, with an AP/non-AP ratio of 1:4. Incidence rate was estimated under Poisson ass...

Potassium-dependent sodium/calcium exchanger (NCKX3) is expressed in the brain, smooth muscle, the uterus, and intestine. NCKX3 gene plays a role in transporting intracellular calcium and potassium ions across the cell membrane in exchange for extracellular sodium ions. This gene is also associated with calcium metabolism in bones. Tight junctions have functional barriers for material transport and osmotic balance, which are regulated by calcium metabolism. Claudin, o...

GH stimulates the growth of skeletal muscle and connective tissue and increases the rate of protein synthesis. Somatotropin (artificial GH) has been commercially available since 1985 and is most commonly used for the treatment of Isolated GH Deficiency, idiopathic short stature, Turner syndrome, Prader–Willi syndrome, chronic renal insufficiency, and ‘small for gestational age’. GH deficiency has a growing prevalence, affecting 20/million children in the UK. Our...

Pre-autonomic neurons in the hypothalamic paraventricular nucleus (PVN) project to sympathetic and parasympathetic motor nuclei in the brain stem, from where the liver and white adipose tissue (WAT) are innervated by both branches of the autonomic nervous system (ANS). Studies by our group and by others have shown that these neural pathways modulate glucose and lipid metabolism in liver and WAT. Given the abundant thyroid hormone receptor (TR) expression in the PVN we hypothes...