Endocrine Abstracts

Objectives: Immune checkpoint inhibitors (ICIs) have demonstrated stunning effects in many cancer types albeit its immune-related adverse outcomes such as hypophysitis, adrenalitis, and thyroiditis. Despite the significant increase in ICIs use in Korea, there still is a lack of clarification about the actual prevalence and risk factors of ICI-associated thyroid diseases.Methods: In this nationwide cohort study, 12,079 lung cancer patients were extrapolat...

Objective: To evaluate computed tomography (CT) features for diagnosing metastatic cervical lymph nodes (LNs) in patients with differentiated thyroid cancer (DTC) and propose CT-based risk stratification system modified from the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) guidelines.Materials and Methods: A total of 463 LNs from 397 patients with DTC who underwent preoperative CT staging and US-guided fine needle aspiration of LNs were in...

Objective: To evaluate the effectiveness and safety of ultrasound-guided RFA for symptomatic distant metastasis of DTC.Methods: The medical records of 12 patients who underwent RFA for palliative treatment of 18 symptomatic distant metastases from thyroid cancer between January 2008 and December 2020 were analyzed. All patients were assessed for their degree of discomfort, and were evaluated periodically as outpatients, clinically, and by imaging and ser...

Background: The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Aim of this study was to evaluate the ability of serum calcitonin and carcinoembryonic antigen(CEA) to predict the extent of surgery needed in the lateral neck in patients with MTC.Methods: This retrospective multicenter cohort study included data from patients with MTC surgically treated in the 6 tertiary medical centers in Korea from 1996 to 202...

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

Background: Sex chromosome mosaic aneuploidy 46,XX/47,XXy (mKS-XX) is a very rare syndrome, with only twenty-one cases previously reported. No patients’ series with mKS-XX and no comparative studies between mKS-XX and the common homogeneous Klinefelter syndrome (KS) have so far been described.Aims: To describe the clinical, biological and socio-professional characteristics of the first series of previously unpublished patients with mKS-XX. To find p...

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...

Aim/hypotheses: Ectopic lipid accumulation in the heart contributes to the abnormal function of the heart and to the death of cardiomyocytes. Saturated FFA is one of the most important causes of death in cardiomyocytes. Although empagliflozin has been reported to be beneficial for people with diabetic complications and/or CVD, it has not been confirmed as to how it affects cardiomyocytes death by FFA. This study was designed to evaluate the protective effects of SGLT2 inhibito...

Iron also plays an important role in many physiological processes, including redox balance, inflammation, and metabolism. It is reported perturbation of iron (Fe) homeostasis has also been associated with metabolic diseases. Iron reduction, with iron chelator, has preventive effects in cardiovascular remodeling and obesity. On the other hand, deferoxamine (DFO) increases hypoxia and collagen production in the kidney. Thus, the effects of DFO on metabolic disease remains contro...

Iodine is a trace element required for thyroid hormone production. Requirements increase in pregnancy, when even mild deficiency may affect offspring neurocognitive development.The gold standard for assessing iodine status is population surveys of urinary iodine concentration (UIC). The WHO also suggests a population prevalence of >3% of TSH values > 5 mIU/L indicates deficiency. A recent UK survey of 700 teenage girls demonstrated ...