Endocrine Abstracts

Background: Body composition of females with polycystic ovary syndrome (PCOS) varies considerably. The literature lacks of skeleton size description in women with PCOS. Objective of the present study was to investigate skeleton robustness in PCOS women.Material and methods: Hundred and one PCOS women (by androgen excess society criteria, mean age 26.85±3.91 years) and 81 healthy control women (mean age 27.95±3.65 years) were investigated in Vil...

Introduction: The signaling involved in ligand-stimulated spermatozoa is not yet clarified. Moreover, the main question in sperm biology is the identification of the sperm ligands. Analysis of the role of MAPK in mammalian sperm physiology is a prerequisite for assigning a role for MAPK in mammalian sperm functions. The unique opportunity to study ERK1/2 in human spermatozoa, which are differentiated cells lacking active transcriptional machinery, will enable to correlate it t...

Introduction: The aim of study was to assess diversity of oxidative stress as a dynamic process throughout metabolic syndrome (MS) continuum ending with coronary heart disease (CHD) or diabetes mellitus (DM).Methods: Main group (MG) of 154 men aged 25–60 years with abdominal obesity (waist circumference above 94 cm) was examined in comparison to 30 healthy men of similar age. In MG 28 men were diagnosed with CHD, 24 – with DM. Fasting glucose (...

Introduction: Effect of GH deficiency on the endocrine function of adipose tissue (AT) is poorly understood. Data on serum adiponectin (ADIPO) concentrations in patients with GH deficiency (GHD) are scarse.The aim of the study was the assessment of ADIPO serum concentrations in adolescents and young adults with GHD and evaluation of their correlations with the degree of GH/IGF1 axis function impairment as well as anthropometric and body composition param...

Introduction: Production of chemerin (CHEM), omentin-1 (OMENT), and vaspin (VASP) in adipose tissue is determined by nutritional status. There is no data on CHEM, OMENT and VASP blood serum concentrations in patients with anorexia nervosa (AN).Objectives: i) Assessment of CHEM, OMENT and VASP serum concentrations in girls with AN. ii) Analysis of correlations between the CHEM, OMENT, and VASP serum concentrations and body weight, BMI, serum insulin (INS)...

Introduction: We have recently described a preformed signalosome associated with the GnRH receptor (GnRHR), which undergoes dynamic rearrangement upon stimulation with GnRH. This signaling complex included c-Src, focal adhesion kinase (FAK), paxillin, vinculin, tubulin, caveolin-1, protein kinase C (PKC) δ, PKCε, PKCα, Ras, kinase suppressor of Ras-1 (KSR), MAPK kinase (MEK) 1/2, ERK1/2 and the GnRHR. To sort out the role of the signalosomes associated with the ...

There are a limited number of studies investigating the immunological alterations accompanying the Sheehan Syndrome. The aim of this study was to evaluate lymphocyte subsets in these patients.Flow cytofluorometry was used for the immunophenotyping of peripheral blood leukocytes from 15 patients (mean age 61.6±11.3, range 34–75 years) and 25 healthy controls (mean age 56.7±10.6, range 34–80 years). The percentages of CD3+, C...

Background: Thyroid damage is known to occur during experimental iodine-induced goiter. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression. Dysregulation of specific miRNAs can interfere with tissue homeostasis. The purpose of this study was to investigate the dynamic expression profiles of miRNAs during adequate or mild-excess iodine supplementation in the iodine-deficient thyroid.Methods: Hyperplastic goiter was induced ...

Although the physico-chemical properties of colloid are not usually considered among the factors regulating thyroid function, it is conceivable that decreasing the viscosity of the intrafollicular colloid may facilitate diffusion of thyroglobulin (Tg) molecules within the lumina. The resulting increase in the number of contacts between Tg molecules and peroxidase at the apical membrane may promote the coupling reaction. Rats on a hormonal diet were given 0.5 μg T4</s...

Introduction: Graves’ hyperthyroidism is an autoimmune disease sustained by autoantibodies binding to and activating the TSH receptor located on the thyroid follicular cell. The objective of study was to determine the presence of anti-receptor TSH antibodies for the diagnosis of Grave’s diseases and the following up after surgery, iodine and treatment with antithyroid drug.Results: In years 2006–2010 in our clinic in 265 patients for thyro...