Endocrine Abstracts

Aim: To evaluate relationships between adipokines (adiponectin, resistin, leptin, interleukin-6, tumor necrosis factor-alpha), insulin resistance and cutaneous vasomotor responses in metabolic syndrome (MS) patients with insulin resistance. MS patients with insulin resistance were divided into two groups: 18 patients with type-2 diabetes mellitus (without insulin therapy and pronounced diabetic complications) (DM) and 18 patients without DM. Of 18 healthy subjects were selecte...

There is strong evidence that genetic factors play an important part in the aetiology of PCOS1 and we have have proposed that PCOS has its origin in fetal life and that, in human females, exposure to excess androgen, at any stage from fetal development of the ovary to the onset of puberty, leads to many of the characteristic features of PCOS, including abnormalities of LH secretion and insulin resistance 2.In postnatal life the natu...

A 67-year-old woman was diagnosed by her GP with hypothyroidism and referred to our department. During the first 2 years after diagnosis, the TSH remained elevated (16–19 mlU/l) with the free T4 ranging 11.1–31.9 pmol/l despite her insistence that compliance with therapy was good and on incremental doses of thyroxine. When seen in the nurse-led thyroid clinic for the first time, concerns were raised to the consultant endocrinologist. Interference with the TSH assay w...

Introduction: Characteristically the discordant thyroid function test has been attributed to TSH-producing hypophyseal adenoma, familial dysalbuminemic hyperthyroxinemia and thyroid hormone resistance syndrome. We presented 2 cases with raised peripheral thyroid hormones with detectable TSH due to the presence of auto-antibodies against the peripheral thyroid hormones (PTAAb). <thead valign="...

Obesity is a complex condition associated with numerous increased health risks caused by reduced physical activity and an increased consumption of energy-dense foods. It affects all ages and socio-economic groups, and is rising to global epidemic proportions.Lifestyle changes in diet and physical activity are capable of treating all but the severest cases of obesity, although low compliance is fuelling interest in effective therapies, including gastroint...

ObjectiveThyroid replacement therapy needs careful titration, and recently there has been discussion regarding the bioavailability of different thyroxine preparations [1]We have taken the opportunity of comparing thyroid function in 18 females who were enrolled in a trial studying the effects of thyroxine therapy on subclinical hypothyroidism [SCH].MethodsThese patients (at entry to tri...

Macroprolactin, a high molecular mass complex of prolactin and an IgG antibody is confined to the vasculature and exhibits limited bioactivity in vivo. Using a panel of sera obtained from 10 subjects whose hyperprolactinaemia was due entirely to macroprolactin this study aims to compare the level of detection of macroprolactin by 9 of the most commonly used prolactin immunoassays.The study involved 24 clinical laboratories employing the following 9 anal...

Metyrapone is a potent inhibitor of the conversion of 11-deoxycortisol (11-DOC) to cortisol and is used in the treatment of Cushing's syndrome. This study has assessed the clinical significance of 11-DOC cross-reaction in five serum cortisol assays provided on automated immunoassay analysers. Cross-reaction was determined from the linear regression of increase in measured cortisol against increasing levels of 11-DOC (0, 1590, 4310, 6490, 7040 nmol/L) added to a serum pool. In ...

Background: Girls with Turner Syndrome (TS) are at increased risk of primary ovarian failure. Previous studies have demonstrated that urinary gonadotrophins (UG) can be used as a non- invasive biochemical marker of pubertal status but their value in monitoring and managing girls with primary ovarian failure is unclear.Aims: To determine the range of UG in girls with Turner Syndrome (TS) and its correlation to serum LH and FSH.Patie...

Background: Nutritional interventions are required for effective management of diabetes Mellitus. Dietary recommendations act as amajor intervention for treatment of D Mand obesity. It is recommended that the diet should be individually adapted to personal choices and metabolic goals. With advent of technology newer monitoring tools like continuous glucose monitoring systems (CGM) are now finding their way into Diabetes management and nutrition therapy. The ambulatory glucose ...