Endocrine Abstracts

The prevalence of diabetes is increasing worldwide. According to the recent World Health Organization (WHO) estimates, more than 180 million people worldwide have diabetes. This number is likely to be more than the double by 2030. It is estimated that the developing countries will bear the brunt of diabetes epidemics in the 21st century. It is well known now that increased rates of other chronic diseases, such as hypertension, obesity, cardiovascular diseases are highly associ...

A 47-year-old, previously healthy, ex-smoker male presented with a two-week history of dyspnea grade 4 with progressive course, palpitations, orthopnea, and paroxysmal nocturnal dyspnea. There was no history of chest pain or fever, but he had noticed recent an unintentional 10 to 15 kg weight loss over the previous 3 months. There was no previous history of cardiorespiratory problems, hypertension, and diabetes. On examination he was dyspenic, anxious and tremulous. His temper...

Introduction: Brown tumor is a rare benign bone lesion with incidence ranging from 1.5% in primary hyperparathyroidism to 13% in secondary hyperparathyroidism. Common sites of involvement are pelvis, femur and ribs, but may appear in any bone. Since the incidence of thyroid disease is higher among patients with hyperparathyroidism than the general population, these lesions must be distinguished from metastases from thyroid carcinoma.We present a patient ...

Steroids are commonly used to treat many chronic illnesses and as part of chemotherapy regimen in children. The hyperglycaemia caused by steroids is poorly recognised and can lead to adverse outcomes. Early recognition and appropriate management of hyperglycaemia is therefore crucial. Fasting blood glucose (BG) levels can be normal and the most sensitive time to test BG is 2 h after lunch.Steroids may also result in secondary adrenocortical insufficiency...

There are no established guidelines on the management of steroid induced diabetes (SID) in children. Steroids are commonly used to treat many chronic illnesses and as part of chemotherapy regimen in children. The hyperglycaemia caused by steroids is poorly recognised and can lead to adverse outcomes. Early recognition and appropriate management of hyperglycaemia is therefore crucial. Fasting blood glucose (BG) levels can be normal and the most sensitive time to test BG is 2 h ...

Objectives: To examine the effect on weight change of diet/lifestyle advice to maintain/achieve a healthy weight in an unselected PCOS population.Methods: All overweight patients attending the Reproductive Endocrine clinic with PCOS are routinely given lifestyle advice for weight loss by their consultant, offered referral to see a dietician and, when clinically appropriate, prescribed orlistat. Clinical notes were reviewed for 50 consecutive patients wit...

Objective: To evaluate the prevalence of the RET mutation and the genotype–phenotype relation in Saudi patients (families) with multiple endocrine neoplasia type 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC).Design: Cross-sectional study.Patients and methods: A total of ten unrelated Saudi families with germline mutation of the RET protooncogene and/or immunohistochemistry diagnosis of MTC were identified. B...

Increased mortality due to atherosclerotic cardiovascular disease has been described in adult patients with hypopituitarism, although the precise underlying mechanisms remain undetermined. Various abnormalities of coagulation and fibrinolysis occur in patients with thyroid diseases. Conversely, there are conflicting reports concerning the effects of growth hormone replacement on coagulation and fibrinolytic pathways in adults with hypopituitarism, and there are limited data on...

Introduction: Many Muslim patients with diabetes observe dawn to dusk fasting during the month of Ramadan. In an observational prospective study, we have used continuous glucose monitoring system (CGMS) to investigate the changes in glucose profiles amongst Muslim patients during Ramadan fasting.Methods: CGMS was applied to patients with type 2 diabetes mellitus (n=14) attending AlZahra Hospital Sharjah for three consecutive days, before (non-fast...

Introduction: Prevalence of diabetes mellitus (DM) in the UAE is around 20% amongst adults. Lifestyle including meal timings are different from the West and may necessitate different treatment schedules. We have used continuous glucose monitoring (CGMS) to look at glycemic patterns in patients with type 1 and type 2 diabetes in the UAE.Methods: Available CGMS data (using methods previously described) on forty-four patients (thirty-one with type 2 DM and ...