Endocrine Abstracts

The clinical presentation of primary hyperparathyroidism (PHPT) has changed dramatically after increased accessibility to biochemical auto-analysers and the diagnosis is today often made by change in patients without specific symptoms. Operative treatment is recommended in patient with markedly increased calcium levels or typical symptoms. However, the vast majority of patients in the modern clinic do not present organ related symptoms and their calcium levels are only slightl...

The clinical presentation of primary hyperparathyroidism has changed dramatically after increased accessibility to biochemical auto-analysers and the diagnosis is today often made by change in patients without specific symptoms. Operative treatment is recommended in patient with markedly increased calcium levels or typical symptoms. However, the vast majority of patients in the modern clinic do not present organ related symptoms and their calcium levels are only slightly incre...

Primary Hyperparathyroidism (PHPT) is the most common disease among parathyroid disorders compared to Chronic Hypoparathyroidism, Calcium Sensor disorders (loss or gain of function mutations) or Parathyroid Cancer. The clinical presentation of PHPT has changed dramatically after the increased accessibility to biochemical analyses. The diagnosis is today often made by change in patients without specific symptoms. Operative treatment is always an option and recommended in patien...

Bone remodeling is a fine tuned process optimizing bone biomechanical properties. Peak bone mass is reached in early adult life, where after bone mass declines in both sexes leading to an increasing risk for low energy fractures. The understanding of bone remodeling has led to pharmacologic treatment of osteoporosis, being different antiresorptive modalities or anabolic treatment with PTH - or analogues. Inherited osteosclerotic bone disorders have been diagnosed since the int...

Classification of pituitary neuroendocrine tumours (NETs) or pituitary adenomas is based on the expression of the anterior lobe pituitary hormones (FSH, LH, GH, Prolactin, TSH, ACTH and alpha-subunit of the glycoprotein hormones). Assessment of the transcription factors SF-1, Pit-1 and T-Pit has been a complement to the classification. Tumours negative for both pituitary hormones and transcription factors have been designated as null-cell adenomas. However, lack of sensitive a...

Background: Bone turnover is increased in active acromegaly. Despite normalization of bone turnover after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not bone mineral density (BMD) is correlated to vertebral fracture incidence. Trabecular and cortical bone are differentially affected by GH and IGF-1. The trabecular bone score (TBS) is related to bone microarchitecture and provides further information not captured by BMD measurement.<p...

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

Background: Growth hormone (GH) is known to have stimulatory effects on bone tissue through a complex interaction of GH, IGF-1 and IGFBPs. The gonadal status is also thought to influence bone metabolism. Bone mass in patients with acromegaly reflects the long-time effects of GH excess on bone. However, data on bone status in acromegaly have been conflicting.Objective: The object of the study was to examine the impact of chronic GH excess on bone mass and...

Purpose: Clinically Non-Functioning Pituitary Neuroendocrine Tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterize the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the clinical course of the tumours.Methods: We investigated the distribution of E- and N-cadherin by immunohistochemistry in a retrospective cohort of thirty tum...

Context: Immediate and sustained cure of acromegaly can only be achieved by surgery, however, most growth hormone (GH) producing adenomas are macroadenomas (≥ 10 mm) at diagnosis, with reported surgical cure rates of approximately 50% compared to microadenomas (<10 mm) with an expected higher cure rate (around 80%). Further, long-term data on remission rates after surgery are sparse. Aim: Estimate short- and long-term surgical remission rates o...