Endocrine Abstracts

Introduction: Persistent or intractable PHPT can lead to neuromuscular and psychiatric symptoms and may increase the long-term risk for cardiovascular disease and fractures. Cinacalcet (Mimpara/Sensipar) represents an innovative treatment option for this small group of patients, as it directly acts on the calcium sensing receptors on cell surfaces, reducing the severity of hypercalcemia.Purpose: To estimate the UK budget impact of cinacalcet in patients ...

The MRC currently operates a ‘highlight notice’ in systems biology for medicine. Highlight notices are requests for applications through the normal response mode route – they represent a priority but do not have a specific budget attached. This notice is of considerable relevance to endocrinology research, as will be discussed at the March meeting. MRC-funded endocrinology researchers are already beginning to use systems approaches with some success, but there i...

Background: There are nearly 5 million people with diabetes mellitus in the UK with an estimated 10% of diabetes patients developing a foot ulcer at some point in their lives. Nearly 9500 diabetes-related amputations are reported in the UK per year and approximately 80% of the NHS budget on diabetes care is spent on treating complications. Limb/life-threatening diabetic foot problems are referred to acute services immediately and all other active diabetic foot diseases are ref...

Dr David Unwin MbChB FRCGP Our GP practice of 9500 people has suffered an eight-fold increase in the number of patients with T2D since 1986. In addition, those affected now develop this condition decades earlier than was the norm back in 1986. A situation replicated all over the developed world. Nationally there are 122,780 children and young adults under the age of 40 years with type 2 diabetes, 1,560 (around 1.3 per cent) are under the age of 19 years. In 2013 our practice d...

Introduction: Among the complications of diabetes ophthalmic are among the most severe. Uzbekistan’s population is over 30 million people; according to statistics the number of diabetes patients is 130 000 people, but the real number is at least six times bigger - more than 800 000 (WHO). Our study aimed to investigate the disability features due to ocular complications of diabetes in Tashkent within 10 years.Methods: Data of examinations in special...

Introduction: Extended up to 20 years follow-up of several randomised control trials showed 34–43% diabetes risk reduction. Real life implementation studies performed worldwide in different settings and populations proved that also non-intensive, low budget lifestyle interventions can be effective. However little is known about long-term results of the translational studies.Objective: To study the risk factors changes of the DEPLAN non-intensive lif...

Introduction: EPODE is a coordinated, capacity-building methodology for communities to implement effective and sustainable strategies to prevent childhood obesity. Since 2008, the EPODE European Network (EEN), supported by the European Commission (DG SANCO), is aimed at facilitating the implementation of interventions using the EPODE methodology in other regions and countries.Methodology: From 2008 to 2011, four committees – gathering universities a...

After a period in research and academia, it is difficult to envisage an alternative career. However, there are a surprising number of opportunities available although it does require some determination to discover them. One of these is to join a medical education, or communications agency. These companies work mainly with pharmaceutical companies and generally cover a range of therapeutic areas. There are many such agencies ranging from those with a small number of employees t...

Background: The association between diabetes and dementia has been well documented (1, 2, 3) and with Australia’s aging population, the already significant disease burden of both pathologies will inevitably progress over time. Despite both being progressive pathologies which escalate over time, there have not been any studies pertaining to degree of glycaemic control and the extent to which this relates to prevalence of dementia.Aims: To determine a...