Endocrine Abstracts

Background: Patients with hypoparathyroidism may present acutely with hypocalcaemia and these patients may have multiple admissions; however, data on the incidence of acute and recurrent acute hypoparathyroidism are scarce in the literature.Aim: We wished to determine: (1) the causes of severe hypocalcaemia amongst A&E attendances (2) the incidence of acute hypocalcaemia due to hypoparathyroidism amongst A&E attendances, and (3) the incidence of ...

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross- sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients contro...

Background: Local guidelines for infants born to mothers with a history of thyrotoxicosis previously recommended that infants were observed in hospital until thyroid function tests were checked on day 4, with follow up on day 10, causing inconvenience to families and unnecessary cost to services. Following a literature search, our revised local guidelines recommend low-risk infants can be discharged on day 0 without follow up, stratified using maternal TSH-receptor antibody (T...

Introduction: The current Endocrine Society guidelines (2010) recommend biochemical and radiological evaluation of men with HH to ascertain underlying hypothalamic and/or pituitary aetiology although the cost-effectiveness of this strategy is yet to be established. We did a retrospective audit to ascertain epidemiology, management and diagnostic outcomes for men with HH in our hospital practice against the current Endocrine society guidelines.Methods: A ...

A 5.65-year-old boy was referred with a 2-month history of accelerated growth and pubic hair development. Weight and height were >98th C. Pubertal assessment was G3 PH2 AH1 TV 5 ml/4 ml. There was no family history of precocious puberty. No birthmarks, or abdominal masses were present. Blood pressure was normal. Investigations revealed elevated testosterone (7.1 nmol/l), suppressed gonadotropins (LH <0.2 IU/l), normal 17-OHP, androstenedione and DHEAS, prepubertal LHRH...

Successful crystallization of TSHR residues 21–260 has been reported (Sanders et al. Thyroid 2007 17 395) using a partial ectodomain (ECD) bound to the Fab fragment of a human stimulating TSHR monoclonal antibody (M22) and its conformational epitopes delineated. We have now studied antibody binding to the entire ECD (residues 1–412) using epitope protection. In this approach, we first protected a highly purified ectodomain fragment with a variety...

Introduction: The two major long-acting somatostatin analogues (SSA) available on the European market for the treatment of neuroendocrine tumours and acromegaly are Somatuline Autogel (SA) and Sandostatin LAR (LAR). The aim of this study was to gain nurses’ insights on the use and ease of administration of SSA devices, including Somatuline Autogel new device (SA-ND), in Europe and the US.Methods/design: Seventy-seven qualified nurses with ≥3 S...

Background: South Asians are at higher risk of vascular disease than the indigenous UK population. Susceptibility to conventional cardiovascular risk factors does not entirely account for this discrepancy. Vitamin D deficiency within this group may be an important patho-physiological contributor and an overlooked treatable cardiovascular risk factor.Aims: To determine whether serum 25-(OH) Vitamin D concentration independently associates with a surrogate...

Pituitary apoplexy is a potentially life and vision threatening neuroendocrine emergency, which can often be misdiagnosed in the absence of the clinical hallmark of sudden onset headache and visual disturbance in a patient previously known to harbour a pituitary tumour. We report a 30 years old male patient with history of Vitiligo who presented to the emergency department with a 1-week history of vomiting, abdominal pain and lethargy along with postural hypotension and a very...

Cinacalcet, a calcimimetic, is licensed for the management of primary hyperparathyroidism (PHP) where surgery is deemed inappropriate. It is unclear when patients might be deemed more appropriately managed by medical treatment rather than surgery. We report two cases in which cinacalcet has been used to predict the effect of parathyroidectomy and a choice to be made between surgery and conservative management.A 43-year-old woman had a parathyroid adenoma...