Endocrine Abstracts

The TEARS database links six datasets for patients with treated and stabilised thyroid conditions. It has been validated previously and represents a population-based patient sample, as patient identification includes using regional-wide biochemical records and prescription data. For patients on long-term thyroxine we examined the outcome of ‘serious vascular events’ defined as vascular death, non-fatal myocardial infarction and non-fatal stroke as used in the Anti -t...

We report 29 years old female with recurrence of adrenal carcinoma and hypercortisolism secondary to HCG responsive adrenal carcinoma.which has been surgically excised in 2003 following the birth of a live infant at 28 weeks gestation.A year latter she presented with a tenderness over the right rib cage and had CT scan which showed metastases at the liver and right renal bed.Hypercortisolism was confirmed biochemicaly with a 24 hou...

Case history: A 35-year-old woman with known hypertriglyceridaemia presented with a one day history of abdominal pain, vomiting and fever. She was 14 weeks pregnant having conceived spontaneously following a period of infertility. She had discontinued her lipid-lowering medication and was managed with diet alone. On examination, she was pyrexial, tachycardic (HR=100 bpm), normotensive (BP=111/71 mmHg), oxygen saturation was 96% on air and she had a tender distended abdomen. A ...

The Endocrine Society recommends urinary or plasma metanephrines as first choice screening tests for phaeochromocytoma due to their high sensitivity. Test specificity is limited by the influence of many commonly prescribed medications resulting in false positive results and additional investigations. The aims of this retrospective study were to (1) Determine the diagnostic accuracy of urinary metanephrines using current cut-off values and (2) Evaluat...

Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014. Record-linkage technology (biochemistry, prescribing, hospital admissions, cancer registration, mat...

The Endocrine Society recommends urinary or plasma metanephrines as first choice screening tests for phaeochromocytoma due to their high sensitivity. Test specificity is limited by the influence of many commonly prescribed medications resulting in false positive results and additional investigations. The aims of this retrospective study were to (1) Determine the diagnostic accuracy of urinary metanephrines using current cut-off values and (2) Evaluat...

Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014. Record-linkage technology (biochemistry, prescribing, hospital admissions, cancer registration, mat...

Introduction: Analysis of epidemiologic patterns in diabetes helps with understanding of etiology, natural history and current and future needs. Bangladesh is a low-middle-income, densely populated country where there is limited information regarding incidence of childhood diabetes.Aim: To assess the type of diabetes in children and young adults in Dhaka, Bangladesh, from July 2011 until June 2016, and estimate minimum incidence of type 1 diabetes (T1D)....

Introduction: Turner Syndrome (TS) is associated with a higher overall morbidity and mortality than the general population, with respiratory diseases as one of the major causes. Haemophilus influenza type B (HiB) and pneumococcal (PC) vaccination can reduce morbidity and mortality, by alleviating the risk of respiratory diseases. All patients in the Newcastle Adult Turner Syndrome clinic who lack immunity to either HiB or PC at baseline receive vaccination in our TS clinic. Ho...

The epidemiology of hyperprolactinaemia is not well characterised in the literature. Using unique patient identifier we were able to link data from biochemistry, prescribing, hospital admissions, radiology, general registry office and maternity data. Observational data was collected for Tayside Scotland between 1993 and 2013. Any patient with a serum prolactin measurement >1000 mU/l or at least three prescriptions for a dopamine agonist were included. Patients who were pre...