Endocrine Abstracts

Fetal ultrasonography is recommended in pregnant women with elevated TSH receptor antibodies (TRAK) or treated with antithyroid drugs in attempt to recognize fetal thyroid dysfunction. We report two cases of pregnant women with Graves’ disease in whom fetal thyroid ultrasonography was especially useful in diagnosing child involvement.A 33-year-old woman at 30-week pregnancy with 3-months history of hyperthyroidism treated with propylothiouracil (PTU...

Adiponectin is a soluble protein produced solely by matured adipocytes. Adipogenesis contributes to the pathogenesis of GO in many ways including a direct effect on proptosis due to increased volume of mature adipocytes.The aim of the study was to estimate an influence of immunosupresive and anti-inflammatory treatment using systemic corticotherapy combined with orbital radiotherapy on serum adiponectin level in GO patients. The study was accepted by Eth...

54-year old woman with Graves’ disease was admitted to Endocrinology Department because of severe thyrotoxicosis and antithyroid drugs inolerance. The apathetic form of thyrotoxicosis was diagnosed; she lost 12 kg during 3 months and she had heavy muscle weakness. Previously she demonstrated allergic skin reactions (macular rushes) after both: Methimazole and Propylthiouracil. At admission her TSH was 0.001 mU/l, fT3 24 pg/ml, fT4 37 pmol/l. Lithium, propranolol and gluco...

The aim of the study was to compare efficacy and tolerability of systemic corticotherapy alone to corticotherapy combined with orbital radiotherapy in severe active Graves’ ophthalmopathy. We studied 905 patients, aged 35–73 years (mean 58.2 ±12), with clinical activity score above 4 and ATA class 3c to 6. Therapeutic outcome was assessed by change in ophthalmopathy index. For 4 weeks all subjects received corticotherapy: 869 - oral prednisone 60–100 mg dai...

Aim: Estimation of the effectiveness of a single low dose 0.05 mg rhTSH in increasing radioiodine uptake (RAIU) before 131I therapy for multinodular toxic goiter with low initial RAIU.Patients: 24 patients (21 women, 3 men) with multinodular toxic goiter without prior antithyroid drug therapy. The initial 24 h RAIU was 21.1±8.44%; range, 6–39% and thyroid volume 64.14±22.49 ml; range, 24.8–109 ml.Meth...