Endocrine Abstracts

In female mammals, the timing of the preovulatory LH surge depends on the combination of the positive estrogen feedback and a circadian signal which synchronizes the LH surge with the transition between the resting and active period at the end of the follicular phase, when arousal is maximal. Previous results have demonstrated that a functional biological clock, located in the suprachiasmatic nucleus (SCN), is required for optimal female fertility. In this context, we have inv...

Introduction: Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Thyroid side-effects such as Graves’ disease have been already described. We describe one case of unusual subacute thyroiditis after alemtuzumab treatment.Clinical case: A 38 year-old-female was treated by alemtuzumab for 2 years. She was referred for hyperthyroidism with 10 kg weight loss, diar...

Insulinoma is a rare neuroendocrine tumor (4 cases/1000000/year), less than 10% are malignant. We report a case of rapidly fatal malignant insulinoma, death occurring less than 3 months after the apparition of hypoglycaemic symptoms.A 79 years old female type 2 diabetic patient, treated with glicazide120 mg b.i.d and metformine et 850 t.i.d, was hospitalized for recurrent hypoglycaemia Insulinoma was diagnosed as severe hypoglycaemic episodes occurred mo...

Cushing’s syndrome (CS) is a rare and complex condition. Once the diagnosis of CS is confirmed, repetitive morning ACTH measurement is indicated to assess whether CS is ACTH dependent or independent. ACTH under 2,2 pmol/l characterises ACTH-independent CS and above 4,4 pmol/l ACTH-dependent CS. Some groups recommend midnight ACTH measurement rather than the morning. The purpose of our work was to evaluate 12PM ACTH vs 8AM ACTH measurement in the etiological diagnostic of ...

Hyperaldosteronism and diabetes are two providers of kidney disease, showing molecular and cellular mechanisms in common, such as oxidative stress, causing renal tubular damages. The objective of this study is to evaluate in vitro the protective effect of a natural antioxidant (red wine polyphenols and green tea extract) in the onset of renal dysfunction. Hyperglycemia and hyperaldosteronism are induced respectively by increasing doses of glucose and aldosterone in prim...