Endocrine Abstracts

Case history: A 50-year-old lady presented with blurred vision in her left eye. She was clinically eupituitary. Visual field testing confirmed a bitemporal field deficit. MRI pituitary showed a pituitary macroadenoma occupying part of the sphenoid fossa and causing significant optic chiasmal compression. The lesion was extending across the left carotid loop, with a part of the lesion extending and compressing the medial aspect of the left temporal lobe. She was found to be hyp...

Aim: To find out all Acromegalic patients above the age of 40 years had their colonoscopic screening or not.Reason for colonoscopy screening: There is 13 to 14 fold increased risk of colorectal cancer in Acromegaly patients and 2.5 fold increase in mortality from Colonic cancer.Standards: i) Patientts with acromegaly should be offered regular colonoscopy from the age of 40 years.ii) ...

Introduction: Prolonged use of topical corticosteroids causes systemic adverse effects including Cushing’s syndrome and hypothalamic–pituitary–adrenal (HPA) axis suppression, which is less common than that of the oral or parenteral route.History: A 31-year-old female patient was referred from the dermatology clinic with symptoms and signs consistent with Cushing’s syndrome. She has been treated for psoriasis with a prolonged course of...

Introduction: The symptoms and signs of thyroid disease can be subtle and non-specific resulting in the indiscriminate use of thyroid function tests (TFT) for diagnosis. The resulting rise in the number of TFTs has raised issues about cost–effectiveness of such a practice. We set out to identify whether using specific clinical indications was an effective way to identify patients with abnormal TFTs and to determine any demographic data that would support unrestricted TFT ...

We present a 35-year-old male who was incidentally found to have a large macroadenoma when he presented with left sided weakness three months ago. He had no headaches or visual disturbances. His prolactin at presentation was >100 000 mU/l (86–324 mU/l). Magnetic resonance imaging confirmed an invasive macroadenoma. His Humphrey’s visual field tests were normal.Rest of the endocrine profile revealed a normal T4 of 14.3 (12–22...

A 37 year old male presented with visual problems in June 2006.He gave a history of double vision for 18 months and denied headaches.On examination his Glasgow coma score was 15/15, pupils were equal and reactive to light. Visual acuity; right eye - 6/6, left eye- 6/60. Visual field testing showed a temporal field defect in the right eye and poor vision in the left eye.MRI brain scan showed a very large, fair...

Introduction: In the UK alone, diabetes affects nearly 4 million people and an additional 13.6 million people are estimated to be at high risk of developing type 2 diabetes (T2DM). Diabetes is associated with vascular complications which path the development of cardiovascular diseases such as strokes and heart attacks. Previous studies have shown various pathways in which hyperglycaemia leads to endothelial dysfunction and insulin resistance. However, current reports of <e...

Introduction: Overweight and obesity is a worldwide chronic disease affecting 2 billion adults and millions of children. In diet-induced obesity (DIO), current treatments are not always effective or suitable for all patients due to the complexity of obesity and its associated health complications. Recently, the potential of developing weight loss therapy by targeting the gut microbiota has been raised. Previously, we have shown that mice overexpressing insulin-like growth fact...

Case report: Central neurocytomas are well-differentiated rare central nervous system tumours. These tumours when identified in brain parenchyma or spinal cord are termed as extra ventricular neurocytomas. We report a case of 40 year old lady with mild hypertension who presented with long standing history of intermittent headaches which got worse 2 months before presentation, mainly affecting her forehead and left retro-orbital region. She also noted blurring of vision in her ...

Objective: To describe the experience of pituitary apoplexy from a single-centre modern series.Methods: We retrospectively reviewed the case notes of patients presenting to Salford Royal NHS Foundation Trust between February 2005 and April 2014 with pituitary apoplexy.Results: A total of 32 cases (20 males) presenting with classical apoplexy were identified, with a mean age at presentation of 54 years (range 22–88 years). 11 p...