Endocrine Abstracts

We describe two cases of sarcoidosis associated hypercalcaemia, renal failure and anaemia mimicking lymphoma. The diagnosis was made by lymph node biopsy. Within weeks of starting oral steroids, symptoms resolved and biochemical abnormalities almost normalized.Case 1: A 66-year-old lady, presented with generalized weakness, lymphadenopathy and splenomegaly. Hb 96 g/l, MCV 91, urea 16.6 mmol/l, creatinine 227 umol/l, eGFR 15 ml/min, serum calcium 3.4 mmol...

Introduction: Artifactual hypoglycaemia has been reported to occur in leukaemia, and also reported in polycythemia Vera, being caused by in vitro autoglycolysis due to an exaggerated consumption of glucose by white blood cells1. We report a case of recurrent hypoglycaemia found to be artifactual secondary to a leukamoid reaction.Case report: A 78-year-old lady with a poorly differentiated endometrial adenocarcinoma was referred to us with a hi...

Gitelman’s syndrome (GS) is an autosomal recessive primary renal tubular disorder with hypokalemic metabolic alkalosis, hypocalciuria, and magnesium deficiency. The association of GS and type 1 diabetes is rare1, and bilateral hydronephrosis and hydroureter has not been reported.A 18-year-old female with known GS diagnosed at 17 years of age and type 1 diabetes diagnosed at 15 years of age was admitted to Leicester Royal Infirmary for pre...

Case history: We report a 38 year-old Caucasian woman with classical salt wasting congenital adrenal hyperplasia (CAH) who increasingly omitted medication in adolescence and eventually spent over 10 years without any adrenal replacement therapy or adrenal crises and became lost to follow up. When seen, she complained of increasing abdominal girth, fatigue, hirsutism, had type 2 diabetes, had never had a romantic/sexual relationship and was amenorrhoeic. Examination revealed ab...

Adrenal/periadrenal sarcomas are very rare entity of adrenal tumours. An epidemiological analysis of primary adrenal cancers found prevalence of adrenal sarcoma of 1.3% compared to adrenocortical carcinoma (ACC) 43.8%, neuroblastoma 39.7%, pheochromocytoma 10.9% and non-Hodgkin’s lymphoma 4.3% (1). In 2021, 26 adrenalectomies in adults were performed in our institution. 12/26 had malignant histology. 9/26 lesions were > 6 cm. 7/9 lesions > 6 cm were malignant (2 a...

Introduction: Pituitary apoplexy (PA) is a rare endocrine emergency with less described entity being its subacute/non-acute presentation. Incidence of PA is difficult to determine, varying 2%-12% of pituitary adenoma. Hypopituitarism in PA is observed in up to 70% of cases with diabetes Insipidus (DI) observed in <5% of cases and mostly transient.Case description: 82-year old female with pituitary macroprolactinoma (1.5 cm) presented with 3-week hist...

Primary hyperparathyroidism (PHPT) is one of the common endocrine conditions and is frequently associated with hypertension and increased cardiovascular mortality but this association is not well recognised. The purpose of this study was to evaluate the effect of parathyroidectomy on blood pressure. The data of 112 patients who attended our out patients clinic over the period of 12 months, with the confirmed diagnosis of primary hyperparathyroidism was evaluated. Average age w...

A 56 year old lady was investigated by her GP for arthralgia and found to be thyrotoxic (TSH < 0.01 mU/l, free T4 34.8 (10–20 pmol/l), TPO 50 (<35 IU/ml)). She gave a history of anterior uveitis some 20 years earlier. She was commenced on carbimazole and referred to the endocrinology clinic, where her thyroid function rapidly normalised and a biochemical diagnosis of subacute thyroiditis was made. Thyroid pertechnatate scan showed reduced uptake throughout the gl...

Excessive ovarian androgen production developing in post-menopausal women can be associated with severe hirsutism and virilisation. In the absence of an identifiable androgen-secreting tumour, medical therapy rather than surgical removal is a potential treatment option. Despite this, the role and outcomes of medical therapy are not well characterised in this context. We present the long-term outcomes of 2 women with postmenopausal ovarian hyperandrogenism, both of whom were tr...

FH, a 36-year-old female of Afghan origin, resident in the UK for 4 years, was referred to the medical services by her obstetrician 9 days postpartum with symptomatic hypocalcaemia. Biochemical investigations confirmed a low corrected calcium (1.43 mmol/l, 2.1–2.6 mmol/l), elevated phosphate (1.76, 0.8–1.45 mmol/l) and alkaline phosphatase (156, 30–130 U/l). Twenty-five hydroxy vitamin D was 16 nmol/l (15–100) with elevated PTH (21.76 pmol/l, 1.05–6.83...