Endocrine Abstracts

Corticotropin-releasing hormone (CRH) and Urocortin 2 (Urn2) are secreted locally in peripheral tissues and play a direct immunomodulatory role as endocrine or paracrine mediators of inflammation. Studies on CRH as well as Ucn2 and vascular endothelial cells suggest that CRH may play a pivotal role in the regulation of vascular endothelial function under normal and pathological conditions. The present study was undertaken to determine whether CRH and Urn2 affect the endothelia...

Introduction: Limited data, support the notion that testosterone induces oxidative stress. Corticotropin-releasing hormone (CRH) participates locally in the endothelial inflammatory response by regulating the pro-oxidative mechanisms of the endothelium, inducing its adaptation to local stress. The present study was undertaken to determine whether the CRH induced pro-oxidant activity in macroendothelial cells under basal conditions, is regulated In vitro by androgen (t...

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

Introduction: There is a great interest in the association of thyroid hormones and mood. Although it appears to be important interactions between the central regulation of mood and the thyroid axis, the effects of antidepressants and especially of selective serotonin reuptake inhibitors (SSRIs) remain ambiguous. We investigated the thyroid function in perimenopausal women suffering from depression.Material and methods: We examined 102 perimenopausal wome...

The presence of lipomas is a characteristic of the syndrome of multiple endocrine neoplasia type 1. The presence of myxomas, however, is a characteristic of Carney syndrome.The aim of the study is the description of a patient with the syndrome of multiple endocrine neoplasia type 1 who presented with a malignant angiomyxoma.A male patient, aged 42 years, presented with intense gastric complaints and was diagnosed with a gastroduode...

Introduction: Several studies have investigated determinants for androgen levels in men, but few studies have included women. Epidemiological evidence has suggested that cigarette smoking has an anti-oestrogenic effect in women, but the effects of smoking on steroid hormone metabolism are not fully understood. We investigated whether there is a relationship between androgen levels and smoking in perimenopausal women.Material and methods: We examined 75 p...

Fine needle aspiration is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy may be reduced by non-diagnostic findings. The aim was to study the effect of nodule size on the diagnostic efficacy of ultrasound-guided fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided fine needle aspiration biopsy was performed in 210 patients with thyroid nodules. Cytology results were compared to nodule size....

Ultrasound-guided fine needle aspiration biopsy is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy is hampered by the presence of non-diagnostic cytology results.The aim was to study the effect of previous thyroxine suppression therapy on the diagnostic efficacy of fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided aspiration biopsy was performed in 45 patients, 31 ...

Adrenal carcinoma is a rare neoplasm with poor prognosis. Mitotane (o,p′-DDD) is the only known therapeutic agent with action on the adrenal. Although it has been used for many decades, its pharmacological properties and exact mechanism of action are still debated. It has been suggested that its therapeutic effect is dose-dependent (Baudin et al 2001). High performance liquid chromatography (HPLC) has been used for the exact measurement of mitotane dose.<p cla...

The detection of antithyroid antibodies, specifically of antithyroglobulin antibodies, in patients with differentiated thyroid carcinoma after near-total thyroidectomy, radioiodine therapy and thyroxine suppression presents difficulties in screening patients for residual disease or recurrence of the disease as it may interfere with thyroglobulin measurement. The aim of the study was to estimate the rate of decrease in antithyroid antibody levels in patients with differentiated...