Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0011oc38 | Neuroendocrinology and neoplasia | ECE2006

Germline mutations in patients with apparently sporadic pheochromocytomas/paragangliomas

Mannelli M , Gaglianò MS , Simi L , Ercolino T , Becherini L , Pinzani P , Sestini R , Bernini GP , Mascalchi M , Genuardi M

Paragangliomas (PGLs) and pheochromocytomas (PHEOs) are neural crest-derived tumors (NCD). PGLs can be localized in parasympathetic ganglia (in the head-neck region or in the anterior thorax) or in sympathetic ganglia (in the posterior thorax or in the abdomen). PHEOs can be considered PGLs arising in the adrenal gland.NCD tumors can present as sporadic or familial. The percentage of hereditary forms is supposed to be 25%. The susceptibility genes predis...
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ea0011p515 | Endocrine tumours and neoplasia | ECE2006

Different scintigraphic patterns between sympathetic and parasympathetic paragangliomas

Gaglianò MS , Simi L , Ercolino T , Becherini L , Sestini R , Mascalchi M , Genuardi M , Briganti V , La Cava G , Olianti C , Mannelli M

Paragangliomas (PGLs) are neuroendocrine tumors arising from the neural crest and localized from the skull base to the pelvic floor. In particular, parasympathetic PGLs arise in the head/neck region (carotid body, vagal nerve, jugulare and tympanic glomus) and more rarely in the anterior thorax, while sympathetic PGLs are localized in the posterior thorax and in the abdomen and secrete catecholamines.Localization of paragangliomas might be performed by a...
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ea0073pep11.3 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Identification of carbonic anhydrases III and IX in the adipose microenvironment of adrenocortical carcinoma

Fei Laura , Cantini Giulia , Nocentini Alessio , Canu Letizia , Nardini Patrizia , De Filpo Giuseppina , Ercolino Tonino , Nesi Gabriella , Maggi Mario , Bani Daniele , Mannelli Massimo , Supuran Claudiu T , Luconi Michaela

The adipose tissue (AT) is an important endocrine organ. Upon energy imbalance, the adipose cells become dysfunctional, supporting the development of metabolic pathologies and tumours. The adipose cell is among the main actor of the tumor microenvironment, and is able to establish a crosstalk with the cancer cell resulting in a reciprocal reprogramming. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy affecting the adrenal cortex. In the most aggressive forms, can...
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ea0040lb13 | Cellular and animal models in Pheochromocytoma/Paragangliomas research: Role of microenvironment | ESEBEC2016

L13 – Biography

Prof. Massimo Mannelli is Full Professor of Endocrinology in the Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence. He is Senior Lecturer in Endocrinology at the Postgraduate School of Endocrinology, University of Florence. He is Director of the Post-graduate School of Endocrinology and Metabolism.He is member of the It...
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ea0049gp123 | Endocrine Tumours | ECE2017

Outcome of patients with adrenocortical cancer after discontinuation of adjuvant mitotane therapy

Terzolo Massimo , Basile Vittoria , Megerle Felix , Hermann Wiebke , Cicciarella Federica , Libe Rossella , Baudin Eric , Haak Harm , Mannelli Massimo , Boscaro Marco , Quinkler Marcus , Bourdeau Isabelle , Perotti Paola , Hahner Stefanie , Beuschlein Felix , Fassnacht Martin

Background: Adjuvant mitotane therapy is frequently used in Europe following surgery for adrenocortical carcinoma (ACC). Management of adjuvant mitotane is mainly empirical and a major open question is the optimal duration of therapy, because no study has ever addressed this issue.Objective: We aimed to assess the outcome of ACC patients who were treated with adjuvant mitotane for at least one year following surgery and then discontinued therapy for othe...
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ea0059oc1.6 | Translational highlights | SFEBES2018

Germline CYP2W1*6 and CYP2B6*6 polymorphisms as predicting markers of sensitivity to mitotane treatment in advanced adrenocortical carcinoma: a multicentric ENSAT study

Altieri Barbara , Herterich Sabine , Sbiera Silviu , Volante Marco , Francia Silvia De , Casa Silvia Della , Pontecorvi Alfredo , Quinkler Marcus , Kienitz Tina , Mannelli Massimo , Canu Letizia , Chortis Vasileios , Kaltsas Gregory , Kroiss Matthias , Terzolo Massimo , Fassnacht Martin , Ronchi Cristina L

Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis and the only approved drug for advanced disease is mitotane. The cytochromes P450 (CYP) 2W1 and 2B6 are proposed predicting markers of sensitivity to mitotane treatment. Aim of the study was to evaluate the relationship between CYP2W1 and/or CYP2B6 polymorphisms and response to mitotane in ACC.Methods: We performed a multicentric retrospective study including 182 ACC patients (F/M=121/61)...
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ea0038oc3.4 | Steroids and adrenal | SFEBES2015

Urine steroid metabolomics as a novel diagnostic tool for early detection of recurrence in adrenocortical carcinoma

Chortis Vasileios , Bancos Irina , Lang Katharina , Hughes Beverly , O'Neil Donna , Taylor Angela , Fassnacht Martin , Bertherat Jerome , Beuschlein Felix , Quinkler Marcus , Vassiliadi Dimitra , Dennedy M Conall , Mannelli Massimo , Biehl Michael , Arlt Wiebke

Introduction: Adrenocortical carcinoma (ACC) is an aggressive malignancy with a high rate of recurrence. Regular post-operative follow-up imaging is necessary, but associated with high radiation exposure and frequent diagnostic ambiguity. Urine steroid metabolomics has recently been introduced as a novel diagnostic tool for the detection of adrenocortical malignancy in patients with adrenal incidentalomas. Here we present the first clinical study assessing the performance of t...
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ea0037gp.28.01 | Endocrine tumours and neoplasia – NETS | ECE2015

Clinicopathologic features, treatments, and survival of patients with ectopic Cushing's syndrome from neuroendocrine tumours: data from an Italian multicentre study

Davi Maria Vittoria , Cosaro Elisa , Piacentini Serena , Reimondo Giuseppe , Albiger Nora , Arnaldi Giorgio , Faggiano Antongiulio , Mantovani Giovanna , Fazio Nicola , Grimaldi Franco , Mannelli Massimo , Giraldi Francesca Pecori , Martini Chiara , Ferone Diego , Campana Davide , Scaroni Carla , Terzolo Massimo , DeMarinis Laura , Francia Giuseppe

Introduction: Available literature on series of patients affected by ectopic Cushing’s syndrome (ECS) deriving from neuroendocrine tumours (NETs) is relatively scarce. This is the first Italian multicentre study regarding clinicopathologic features, modalities of treatment, and survival of patients with NETs and ECS.Patients and methods: Retrospective analysis of data from patients with ECS from NETs collected in 14 centres between 1986 and 2014, ob...
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ea0019oc14 | Neuroendocrine and Steroids | SFEBES2009

Urinary steroid profiling as a biomarker tool for the detection of adrenal malignancy: results of the EURINE ACC Study

Arlt W , Hahner S , Libe R , Hughes BA , Biehl M , Stiekema H , Schneider P , Smith DJ , Shackleton CHL , Opocher G , Bertherat J , Allolio B , Mannelli M , Mantero F , Fassnacht M , Bertagna X , Stewart PM

Adrenal tumours have an incidence of 2–3% in the general population. Adrenocortical carcinoma (ACC), a highly malignant tumor with a poor prognosis, has an annual incidence of two per million but representation in pre-selected patient cohorts with adrenal masses undergoing surgery is up to 12%. Differentiating adrenocortical adenomas (ACA) from ACC represents a continuous challenge, with unfavourable sensitivities and specificities provided by tumour size, imaging criteri...
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ea0056gp24 | Adrenal clinical | ECE2018

Germline CYP2W1*6 polymorphism is a new predictive marker of sensitivity to mitotane treatment in advanced adrenocortical carcinoma: a multicenter European study

Altieri Barbara , Herterich Sabine , Volante Marco , Sbiera Silviu , De Francia Silvia , Casa Silvia Della , Pontecorvi Alfredo , Quinkler Markus , Kienitz Tina , Mannelli Massimo , Canu Letizia , Chortis Vasileios , Kaltsas Gregory , Kroiss Matthias , Terzolo Massimo , Fassnacht Martin , Ronchi Cristina L

The cytochrome P450 2W1 (CYP2W1) is an orphan enzyme able to activate anticancer pro-drugs and to metabolise endogenous substances as fatty acids and lysophospholipids. Aim of the study was to evaluate the frequency of CYP2W1 polymorphisms in patients with adrenocortical carcinoma (ACC) and correlate it with the sensitivity to mitotane, which represents the only approved drug for the treatment of advanced ACC.Methods: A multicenter retrospective study in...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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