Endocrine Abstracts

Introduction: Malignant melanoma is a challenging illness for researchers due to unknown hormonal disorders involved in promoting/developing this disease. Some authors accept nowadays, that prolactin is involved in extrapituitary carcinogenesis.The authors aimed to study the status of prolactin in patients with melanocytic lesions and the impact of surgical removal on prolactinemia.Method: The study included 128 adults with melanom...

Background: PCOS-associated increased metabolic risk may be selective, owing to its heterogeneous nature. Identification of high-risk individuals could enable better studies and prevention of complications.Aim: To characterize the metabolic risk, as metabolic syndrome (MetS), of specific PCOS subphenotypes.Subjects and methods: Romanian PCOS (Rotterdam criteria) and 64 controls, 18–35 years. PCOS subphenotypes were defined: i)...

Introduction: Patients with non-functioning pituitary adenomas (NFPA) and hipopituitarism had a reduced life expectancy.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in patients with NFPA in the last decade.Methods: A 196 patients (83 F/113 M, mean age 52.7±0.9 years) with NFPA admitted in a single Neuroendocrinology Department between January 2001 and December 2010 were retrospec...

Background: A large spectrum of AIP gene mutations has been identified in familial and sporadic pituitary adenomas (PA) with over 70 different mutations described to date. c.47G>A, p.R16H is an AIP exon 1 variant of unknown significance, its contribution to pituitary adenoma development being controversial.Aim: Characterization of p.R16H prevalence in a large Romanian cohort of PA patients and controls.Patients and methods: spo...

Background: Hyponatremia is a common electrolyte abnormality, especially in elderly, hospitalized patients, with a prevalence of severe hyponatremia (<125 mmol/l) up to 6–8%. Pituitary insufficiency (TSH+ACTH) may be difficult to diagnose, but it is important to differentiate it from SIADH and cerebral salt wasting syndrome.Aim: To describe the aetiology and outcome of patients with hyponatremia due to pituitary insufficiency in a tertiary endoc...

Introduction: The quantitative ultrasound (QUS) is an useful tool in the evaluation of the fragility fracture risk.Aim and study design: We performed the QUS fragility fracture risk groups (valided by the golden standard DXA) by a unifactorial analyze including the bone markers.Method: The cut offs used were: SI≤59U (high risk), SI≥83U (low risk), and medium risk with SI between 59 and 83U. The QUS analyze was performed...

Background: Cushing’s syndrome (CS) is associated with a hypercoagulable state and an increased risk for acute coronary syndromes, stroke, and deep vein thrombosis (DVT).Aim: To assess the prevalence of thrombotic events in a series of patients with CS.Patients and methods: Notes of 113 patients with CS were retrospectively reviewed.Results: Instable angina was diagnosed in ten women, aged 52.1±12.2...

Background: Endocrine hypertension accounts for around 3% of the secondary forms of hypertension and screening of young hypertensive patients for secondary causes is mandatory.Aim: To present difficulties in endocrine assessment of arterial hypertension in people younger than 40 years.Patients and methods: Twenty-two patients (15 M/7 F), aged 27.1±7.7 years (range:16-40 years), with systemic hypertension (systolic blood pressu...

The structural and functional effects upon arterial vessels of GH and IGF1, chronically elevated in active acromegaly, are risk factors for premature atherosclerosis, but current therapies can normalize GH and IGF1 production.Aims: To evaluate if carotid wall alterations in acromegaly are reversible after disease control.Material and methods: Fifteen patients with controlled acromegaly (CA) after multimodal therapy (45.5±</...

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...