Endocrine Abstracts

Introduction: An audit of outcomes and indications for parathyroidectomy was conducted from April 2016 to April 2018 for all patients had primary hyperparathyroidism at East Sussex Hospitals Trust.Methods: Clinical notes, pathology results and radiology results were accessed to compile the dataset. Indications for surgery were based on the National Institute of Health criteria for parathyroidectomy in hyperparathyroidism from 2013....

Metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), are increasing in prevalence. Steroid hormones are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human liver, inactivating steroid hormones, including glucocorticoids and androgens. The human AKR1D1 gene contains 9 exons; six splice variants have been identified and three lead to functional protein isoforms (AKR1D1-001, -0...

Case history: A 26 year-old lady was admitted directly from the endocrine clinic with severe hypertension (BP 180/130 mmHg) and bilateral papilloedema. Six weeks prior to admission she had undergone resection of a 24 cm right upper quadrant lesion that was pre-operatively felt to be of hepatic origin. She was normotensive pre-operatively. Histology confirmed this to be an adrenal phaeochromocytoma with deficient SDH immunostaining. Pre-operative biochemical assessment had not ...

Case History: In 2011, an asymptomatic 63-year-old professor was found to have isolated hypokalemia. He was normotensive and his only past medical history was hypercholesterolaemia. Investigations were suggestive of Primary Hyperaldosteronism (PHA): aldosterone 1055 pmol/L, renin mass 10 mU/L, Na+137 mmol/L, K+3.2 mmol/L, bicarbonate 31 mmol/L. A CT scan was reported as normal, but a 12mm nodule was subsequently noted contiguous with the left adrenal. A m...

Background: Guidance on pubertal-induction in hypogonadal adult men is sparse. For adolescent boys, in whom delay is usually constitutional, treatment is typically initiated with pulsed low-dose IM testosterone (T); the dose being progressively increased if/when it becomes clear that endogenous gonadotrophin secretion is not being initiated. In teenagers with organic hypogonadism, the aims are to recapitulate the normal tempo of puberty over 2–3 years and optimise linear ...

Methodology: Polycystic ovary syndrome (PCOS) has a variety of signs and symptoms compromising different phenotypic presentations. Insulin resistance is a known association of PCOS. Despite the documented effect of ethnicity on insulin resistance, there is little known about the effect of ethnicity on the clinical presentations of PCOS. We compared the clinical presentations of white and South Asian (SA) women with PCOS.Methodology: Retrospective analysi...

Objectives: (1) to establish the relative level of osteoporotic fracture in the thyroid population compared to the general population, and (2) to establish whether osteoporotic fracture in patients receiving thyroxine was associated with plasma thyroid stimulating hormone (TSH) level or thyroxine dose.Method: A database of clinical information from subjects with treated thyroid disease was linked to morbidity records describing all in-patient episodes of...

Backround: Male hypogonadism is associated with an increased incidence of cardiovascular risk factors and approximately 25% of males suffering with coronary heart disease are hypogonadal. Few studies have assessed the impact of testosterone therapy on vascular function in hypogonadal individuals and none have investigated the weekly impact of gradually reducing testosterone concentrations on vasculature.Patients and Methods: 10 hypogonadal subjects (6 wi...

Backround: Recent research has heightened the controversy surrounding the effects of conventional hormone replacement therapy on cardiovascular risk, suggesting that use of HRT is associated with an increase in cardiovascular morbidity and mortality. Testosterone has also been associated with unfavourable cardiovascular parameters and the addition of testosterone to HRT may augment the risk of cardiovascular events in postmenopausal women.Aim: To elucida...

The cell cycle occupies a pivotal role in the control of cellular proliferation, a critical point being activation of CyclinE which is held in check by the inhibitor p27. CyclinE is targeted for degradation by the F-box protein Archipelago (Ago/Fbw7/cdc4), while p27 is exported out of the nucleus by Jun activation domain-binding protein 1 (Jab1). Over-expression of CyclinE has been reported in breast cancer. We have now explored the role of Jab1 and Ago in mediating changes in...