Endocrine Abstracts

Case History: We present a case of a 33-year-old woman who attended with heart failure whilst awaiting a surgical resection of phaeochromocytoma. She presented hours after an intravenous iron transfusion to treat her known iron-deficiency anaemia secondary to menorrhagia from massive uterine fibroids, for which she under the care of the gynaecology team. She was known to have a right-sided phaeochromocytoma, which was found incidentally on MRI in 2021, and was taking phenoxybe...

Case History: A 19-year-old female presented with painful left shoulder after slipping whilst doing press-ups. Plain x-ray showed a proximal humeral fracture, as well as a large bone cyst raising concerns of a pathological fracture. She had no past medical history and was not taking any regular medications. On further questioning she did complain of a 2 year history of bilateral painful shoulders and left knee pain. Family history was significant for her father suffering prima...

Aim: Acromegaly is associated with multiple co-morbidities including diabetes mellitus (DM), obstructive sleep apnoea (OSA), arthropathy, cardiovascular events and malignancies. Early diagnosis and treatment, with an intention to cure or control the growth hormone (GH) exposure can reduce risk of these complications. The aim of this study is to assess the development of acromegaly-related complications amongst patients who have completed at least 10 years of follow up after ac...

Introduction: Pulmonary NENs account for around 2% of all pulmonary malignancy. They are classified histologically into 4 types typical and atypical carcinoids which are generally well differentiated and large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) which are poorly differentiated. Within the literature there are several reports regarding overall survival on small mainly surgical cohorts, but data for the UK population are lacking. Only a few...

Introduction: Up to half of patients with carcinoid syndrome develop carcinoid heart disease; this is thought to be mediated by serotonin from disordered tryptophan metabolism. Valve degeneration can lead to right heart failure which drives morbidity and mortality in this patient population. Surgical replacement of affected valves is an effective therapy. Peptide receptor radiotargeted therapy (PRRT) has demonstrated better progression-free survival compared to high dose sando...

Introduction: Perioperative mortality of patients who undergo heart valve surgery for carcinoid heart valve disease (CHVD) has been observed to be high (5–10%). We investigated whether peptide receptor radiotherapy (PRRT) with Lutetium-177 Dotatate can be used safely in patients with neuroendocrine neoplasms (NEN) and CHVD and if there is an associated survival advantage by reducing overall exposure of the valves to high doses of vasoactive peptides.<p class="abstext"...

There is limited research into the impact of active brown adipose tissue (aBAT) in patients with phaeochromocytomas and paragangliomas (PPGLs). A small body of evidence has shown that patients with PPGL patients can exhibit a high prevalence for aBAT recognized as ranging between 8 - 28% without specific correlation to germline mutations. Furthermore, it has been suggested that aBAT may be linked to increased mortality. Systematic searches of the Medical Literature Analysis an...

Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Following biochemical confirmation of aldosterone excess, adrenal venous sampling (AVS) is the gold standard investigation to lateralise the source of aldosterone hypersecretion in patients deemed suitable for potential adrenalectomy. AVS has been performed for all suitable patients with a diagnosis of PA in Beaumont Hospital since implementation of a new protocol involving collaboration between End...

M O Thorner, University of Virginia, Charlottesville, VA, USA AbstractMichael O. Thorner is David C. Harrison Teaching Professor of Internal Medicine. He previously was Kenneth R. Cripsell Professor, Chief of the Division of Endocrinology and Director of the General Clinical Research Center and Henry B Mulholland Professor and Chair, Department of Internal Medicine at the University of Virginia. He is a fellow of the A...