Endocrine Abstracts

Introduction: It has been documented that autoimmune thyroiditis (AT) predisposes to the development of papillary thyroid cancer (PTC). The presence of chronic inflammation was thought to act as an initiating factor in carcinogenesis. Moreover elevated levels of TSH found in hypothyroid patients with AT were speculated to stimulate follicular epithelial proliferation and thereby promote the development of PCT.Case: We describe a case of two sisters aged ...

Cystic fibrosis related diabetes (CFRD) is the commonest co-morbidity in CF leading to increased mortality rates. The pathophysiology includes pancreatic fibrosis, reduction in α and ß-cell mass, delayed insulin secretion and variable insulin insensitivity. Insulin production can fluctuate with progression over time to an insulinopenic state. We report two cases of young people with CFRD with high insulin requirements, poor glycaemic control and improvement with the ...

A 22-year-old male presented to the Emergency Department with nausea and vomiting. He reported thirst, polyuria, reduced appetite and weight loss. He did not have pre-existing medical conditions and did not take regular medications. On examination, he appeared pale and clammy. He was apyrexial, tachycardic and tachypnoeic with normal blood pressure and oxygen saturation. His chest was clear and abdomen generally tender. A venous blood gas revealed pH 6.94, base excess −2...

Introduction: Neonatal biochemical screening programmes for congenital hypothyroidism (CH) allow early diagnosis and treatment of infants with CH, thereby efficiently preventing mental retardation. The purpose of the study was to assess the predictive role of Tc-99m pertechnetate thyroid scintigraphy in differentiating between transient and permanent hypothyroidism in neonates with borderline TSH results (6–19.9 μ/l) at the screening.Methods: A...

Introduction: T1DM is an autoimmune condition. At diagnosis, 80% of patients have positive glutamic-acid decarboxylase antibodies (GADA). We report a case of T1DM diagnosed 1 year after the onset of autoimmune limbic encephalitis (LE).Case: A 13-year-old female was diagnosed with voltage-gated-potassium channel (VGKC) positive LE after presenting with complex partial seizures and auditory hallucinations. A year later and prior to the diagnosis of diabete...

Introduction: A number of different parameters are used to assess adequacy of treatment in children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hydrocortisone day curves are established practice in our unit. To determine the value of this procedure, outcomes were monitored using the European Society for Paediatric Endocrinology 2002 guidelines for the management of 21-hydroxylase deficiency.Methods: Two hourly cortisol profiles ...

In Europe the trace element selenium has been shown to be diminished on farmland and consequently in the food chain. Selenoproteins play a major role in the redox-systems of the body; glutathion-peroxidase is important for the enzymatic reduction of hydroperoxides in the thyroid gland. Furthermore, various forms of dejodases contain selenium, which convert thyroxin into triiodthyronin.We investigated the incidence and the extent of selenium deficiency in...

Due to early demission of women soon after parturition neonatal (nn) TSH-screening of the new born becomes a problem. Therefore we investigated, whether measurements of TSH (Units per liter), free thyroxine (fT4 picogram per millilitre) and antibodies against thyroxine-peroxidase (a-TPO, Units per millilitre) in cord blood of spontaneously delivered babies at term, might be an alternative. Routine (nn) TSH-screening was recommended to be carried out on day 5 of life. Their mot...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...