Endocrine Abstracts

Introduction: Low endogenous testosterone levels are related to the metabolic syndrome /MS/ and diabetes type 2 in middle-aged and elderly men, but little is known about interrelations testosterone-insulin in younger hyperinsulinemic men. Recent studies have shown that the night melatonin in males with hypogonadotropic hypogonadism is significantly higher in comparison with the healthy men, while it is significantly reduced in patients with hypergonadotropic hypogonadism. Howe...

Aim: The present study aimed to compare the androgen levels in men with obesity, metabolic syndrome /MS/ and healthy normal – weight controls.Materials and methods: Eighty-six males (mean age 29.65±8.57 /18–50/) were investigated. 31 of them were healthy (mean BMI – 23.66±1.97); 22 were with simple obesity (mean BMI – 32.79±7.16) and 33 (mean BMI – 35.78±8.71) were with overt metabolic syndrome /MS/ according ...

Recently was established, that in the ovary Anti-Müllerian hormone (AMH) is produced by the granulose cells and correlated with the count of small antral follicles. As AMH is largely expressed throughout folliculogenesis, it is considered that the serum levels of AMH may represent both the quantity and quality of the ovarian follicle pool. To determine the changes of AMH in women with polycystic ovary syndrome (PCOS) we have studied 22 patients with this disorder and comp...

The androgen receptor (AR) polymorphism is determined by a variable number of CAG triplets in exon 1 of the AR gene, located on the X chromosome. CAG polymorphism could modulate different hyper- or hypoandrogenic conditions, but its influence on the polycystic ovarian syndrome (PCOS) in different ethnic populations is controversial. Therefore, we investigated the influence of the AR polymorphism on the hormonal factors and clinical signs in 52 women with PCOS and in 41 non-hir...

Androgen receptor (AR) containes a variable polyglutamine chain that is determined by the different number of CAG repeats in the AR gene on the X chromosome. The transactivational competence of AR is inversely related to the length of the polyglutamine chain, respectively to the CAG repeat number. Therefore, we investigated the role of the androgen receptor polymorphism in healthy hirsute and non hirsute women.CAG repeat length polymorphism was analyzed ...

Aim: The aim of the study was to compare the semen quality in men with metabolic syndrome/MS/ and healthy controls.Materials and methods: Semen samples were collected from 35 males (mean age – 27.45±8.00 years). Nineteen of them had the features of the metabolic syndrome according to the IDF definition and 16 were healthy volunteers. The semen samples were analyzed by only one experienced researcher according to the World Health Organization gu...

Background: Insulin secretory defects and insulin resistance exists in women with polycystic ovary syndrome (PCOS) and are prerequisites for the development of type 2 diabetes (T2D). we aimed to determine the prevalence of T2D, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), as well as the factors associated with these dysglycemic conditions in this population.Methods: 1614 PCOS women of Caucasian origin (Rotterdam criteria) with a m...