Endocrine Abstracts

Introduction: Teriparatide is an osteoanabolic agent approved for the treatment of osteoporosis in postmenopausal women, in men with increased fracture risk, and in glucocorticoid-induced osteoporosis. The aim of this study was to evaluate the real-world use and efficacy of teriparatide.Patients and Methods: We retrospectively assessed all patients with available data, who received teriparatide at Leeds Teaching Hospital...

Case history: A male patient presented to the Endocrine clinic age 64, with an 18-year history of erectile dysfunction. He was treated under Urology with phosphodiesterase inhibitors and Nebido injections for hypogonadism. Notably the cause of hypogonadism had not been established. The patient was concurrently reviewed by Oral Medicine due to a 2.5-year history of xerostomia, and Dermatology for a non-healing, erythematous, pruritic lesion on his right lower leg and several wh...

Introduction: Ipilimumab is a human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 (CTLA-4) that has been shown to significantly improve survival in patients with metastatic melanoma. Immune-related adverse events (irAEs) occur in some patients with increased T-cell activation, of which ipilimumab-related hypophysitis (IH) is an important treatment complication. The aim of this study is to determine the incidence of IH and characterise clinical presentat...

Introduction: Checkpoint inhibitors (CPi) are finding a place in the treatment algorithm of an increasing number of cancers. Immune-related (ir) endocrinopathies are frequent side-effects. Diabetes mellitus (irDM) is infrequent, but often presents acutely and can be potentially life-threatening There are ˜60–70 cases characterising irDM in the literature. We describe 4 cases of irDM to add to the understanding of this condition. All four patients were undergoing trea...

Objective: Radiotherapy (RT) can achieve tumour control rates of over 90% in pituitary adenomas. The commonest toxicity of irradiation is hypopituitarism. The exact incidence is variable and requires long-term testing for deficiency of all hypothalamic-pituitary axes (HPA). The aim of this study is to determine the time to onset of individual hormonal deficiencies and establish a timeframe for endocrine testing post-RT.Methods: We retrospectively assesse...

Background: Diagnosing secondary hypothyroidism can be challenging, particularly for patients with low-normal free T4 (fT4). Thyroid hormone replacement (THR) in these cases is guided by the normal population fT4 range. The aim of this study was to compare thyroid function tests in thyroid cancer patients on THR and patients with pituitary diseases with or without central hypothyroidism.Methods: We retrospectively collect...

Background: Antithyroid drugs (ATDs) are preferred as a first-line treatment for Graves’ disease (GD). However, around 50–60% of patients relapse following treatment withdrawal. Radioactive iodine (RAI) or thyroidectomy is recommended for these patients, however, repeat ATD therapy is a further option, dependent upon patient choice. The long-term efficacy of ATD in relapsed GD has not been robustly established.Methods: We conducted a retrospect...

Background: Current therapeutic options for Graves’ disease (GD) include antithyroid drugs (ATD), radioactive iodine (RAI) or thyroidectomy. ATD treatment is widely used but the relatively high recurrence rate (~50%) after ATD discontinuation is a major concern. Identification of risk factors predicting relapse in GD patients after stopping ATD is decisive to guide initial treatment choices.Methods: We conducted a retrospective study to determine th...

Objective: Determinants of why only a subset of patients with adrenal insufficiency (AI) experience recurrent adrenal crises (AC) and intercurrent illnesses are not well understood. This study aimed to identify whether residual adrenal function (RAF), defined by the peak response to a provocative test undertaken before commencing glucocorticoids, may help explain differences in prevalence.Design and Methods: Patients wit...

Background: Endoscopic trans-sphenoidal surgery is a technical advance for treatment of pituitary tumours. We present the outcomes of patients with Acromegaly or Cushing’s disease undergoing selective pituitary adenomectomy in a regional neurosurgical centre.Methods: Retrospective cohort study August 2010-August 2017. Imaging, histology and pituitary hormone assessments were collated pre and post-operatively to...