Endocrine Abstracts

BackgroundPancytopenia due to hypopituitarism has been reported previously in the literature. Most of these case reports relate to hypopituitarism secondary to Sheehan’s syndrome. We report a case of isolated ACTH deficiency causing pancytopenia which was successfully treated with hydrocortisone replacement.Case history: A 71-year-old lady with a known history of treated hypothyroidism and learning disabilities was referred to...

A 33-year-old woman was referred to our service for investigation of secondary amenorrhea. She is from India and moved to the UK 8 years ago. She has two children aged 7 and 4 years. She has a history of TB adenitis treated in 2007 with quadruple anti TB medication for 6 months. She was told she had no pulmonary involvement and was clear after treatment. She is currently on no medication. During 2012 she noticed her menstrual cycles were lengthening with amenorrhoea since Janu...

Autoimmune hypophysitis (AH) is characterized by lymphocytic infiltration and eventually destruction of the pituitary tissue. AH accounts for ~1% of pituitary masses and 0.5% of hypopituitarism. Although it has been recognized as an uncommon pituitary disease, its true frequency is not known but certainly underestimated. AH may affect pre- and post-menopausal women, men and children, but most cases are reported in women during reproductive age. AH may be associated with other ...

Introduction: Dabigatran is a direct thrombin inhibitor which is used for reducing the risk of stroke or systemic embolism in patients with atrial fibrillation. Although INR monitoring is not required in the course of treatment, it may be complicated with spontaneous systemic bleeding. Sheehan’s syndrome is characterized with panhypopituitarism which is caused by necrosis of the pituitary gland. Recent studies have demonstrated that panhypopituitarism is associated with b...

Background: Hyponatremia is a common electrolyte abnormality, especially in elderly, hospitalized patients, with a prevalence of severe hyponatremia (<125 mmol/l) up to 6–8%. Pituitary insufficiency (TSH+ACTH) may be difficult to diagnose, but it is important to differentiate it from SIADH and cerebral salt wasting syndrome.Aim: To describe the aetiology and outcome of patients with hyponatremia due to pituitary insufficiency in a tertiary endoc...

Introduction: Pituitary insufficiency of the adult is a rare pathology (~30–40/1 000 000 per year). Among the acquired causes, Sheehan syndrome (SS) is often characterized by an insidious evolution, which allows it to pass unnoticed for a long time.Case report: R Maria, 58 years-old, known with SS for 10 years, was hospitalized in the ER with severe asthenia, obnubilation, symptomatic arterial hypotension. Laboratory studies revealed severe hyponatr...

Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiological entity characterized by seizures (91.7%), headache (83.3%), visual disturbance (62.5%),encephalophathy (29.2%), and paralysis (8.3%). Co-morbidities included systemic lupus erythematous (29.2%), kidney disease (20.8%), eclampsia(20.8%), renal artery stenosis (12.5%), Takayasu arteritis (4.2%), Sheehan's syndrome(4.2%), and acute intermittent porphyria (AIP) (4.2%). We report a 31-year-old woman w...

The diagnosis of the adrenal insufficiency requires complex clinical, laboratory and imagistic investigations. The study group was represented by 59 cases of adrenal insufficiency hospitalized in the Clinic of Endocrinology Timisoara, Romania, during the period 2000–2010 (age=42.10±16.30 years; F/M ratio=43/16). The patients were divided in two groups: primary adrenal insufficiency (42.37%) and secondary adrenal insufficiency (57.63%). In the group of primary adrenal...

Introduction: Hundred years ago Harvey Cushing attempt first human pituitary transplantation. This operation, in different modifications, was performed in the next 50 years, but now is used rather only in animal experiment. The problem of effective therapy of hypopituitarism, other that substitution, is however still open. That encouraged us to present a patient 50 years after pituitary xenotransplantation.Case: A 75-year-old woman was admitted to hospit...

Objective: Hypopituitary patients receiving convensional hormone substitution, but without growth hormone (GH) replacement, have an increased mortality from cardiovascular disease. The aim of the present study was to assess the heart rate variability(HRV) in hypopituitary patients with severe GH deficiency.Material and method: Thirty-five patients (20 women, 15 men, aged 23-75 years) with severe GH deficiency, all of 35 patients with low insulin-like gro...