Endocrine Abstracts

Objectives: The Tier 3 Weight Management (WM) service is a comprehensive pathway for people with a Body Mass Index (BMI) >40 or >35 with complications. This study aimed to describe the clinical characteristics and outcomes in patients referred to the WM service in Birmingham and Solihull (BSol).Methods: This was a retrospective health service evaluation of adults consecutively referred to the BSol WM service from March 2017 to April 2018. Data wa...

Background: Hyperinsulinemic hypoglycaemia (HH) after Roux-en-Y gastric bypass (RYGB) is rare. Patients typically present with post-prandial hypoglycaemia >1 year after surgery and once weight loss has plateaued. Despite multiple treatment options, the management of these patients remains challenging.Clinical case: A 31-year-old female was referred for bariatric surgery with a BMI of 41.4 kg/m2. In the year preceding the r...

Background: People with Primary adrenal insufficiency (PAI) were identified as a vulnerable group by the UK government during the COVID-19 pandemic. Hence our aim was to evaluate the incidence of COVID-19, and associated adrenal crisis (AC) in people with PAI in the UK.Methods: A prospective observational study of patients with PAI was performed between January-June 2022. Participants were recruited via the Addison’s Disease Self Help Group. Diagnos...

Introduction: Obstructive Sleep Apnoea (OSA) is more common in women with Polycystic Ovary Syndrome (PCOS). There is paucity of data regarding the impact of OSA in women with PCOS.Methods: We conducted a retrospective study using electronic patients’ records of premenopausal women with PCOS who were first seen in the weight management clinic (WMC) between March/2008 and November/2014. PCOS diagnosis was documented either by referring clinician or es...

Introduction: Guidelines have, for some time, suggested a lower threshold for surgical intervention in primary hyperparathyroidism based on serum calcium alone. Furthermore, PHPT is a common metabolic bone disorder which is associated with further complications. In order to assess the impact of the lower threshold on surgical services and management implications for associated complications, we report baseline characteristics in a cohort of patients with confirmed PHPT.<p ...

Introduction: Eighty percent of patients with PHPT have co-existing vitamin D deficiency. Few large studies have assessed the impact/safety of different vitamin D preparations on calcium, PTH and vitamin D in such patients. We report the use of three different preparations.Methods: In a retrospective study of 125 patients with confirmed PHPT, 77% were vitamin D deficient (<30 nmol/l)/insufficient (30–50 nmol/l). We assessed the impact and safety...

Background: Body Mass Index (BMI) and waist circumference (WC) are currently used to assess obesity. BMI and WC do not take into account fat/muscle distribution or allow for distinctions between gender, age or ethnicity. WC reflects abdominal fat distribution more accurately, but is operator-dependant and variable in terms of reproducibility. BVI is a totally new, reproducible and novel concept using a 3D body scanner and appropriate software, to measure total body and 8 body ...

We report a 47-year old lady who was initially diagnosed to have primary hypothyroidism nearly four years ago; on treatment with levothyroxine sodium (LT4) 150 μcg daily. Despite reasonable doses of LT4, and being fully compliant with her therapy, at no stage her TSH was less than 20 mU/L (Table-1). Malabsorption was ruled out and there were no clinical features to suggest this. When she was reviewed...

Aim: To audit radioactive iodine (RAI) treatment.Methods : A retrospective audit of thyrotoxic patients, who attended the one-stop RAI clinic, between April 2005 and February 2006.Results: We included 74 patients (60 females, 14 males) with a median age 54 (22–85) years.Before RAI: Smoking history was recorded in 19/74(26%) patients. 44/74(59%) patients received drug treatment for two years or mor...

Background: The incidence of adrenal crisis remains constant, despite the introduction of behavioural interventions to educate and empower patients. To increase the success of future behaviour change interventions, theoretically informed and empirically supported behaviour change frameworks are available. The current review aimed to identify and evaluate available evidence of interventions used to prevent adrenal crisis in people with primary adrenal insufficiency to inform fu...