Endocrine Abstracts

Study objective: To study blood pressure (BP) levels and aortic dimensions in women with Turner syndrome (TS).Materials and methods: 102 women with TS (mean age 37.7 years; 18–62 years). 24 hour ambulatory BP measurement and echocardiography was performed on participants.Results: Mean BP systolic (sys) and diastolic (dia) values were (±SD): sysBPday 128.0±15.3; diaBPday 81.6±11.8; sysBPnight 110.4...

Women with Turner syndrome (TS) more frequently develop cardiovascular disease. Abnormal lipid metabolism is a well known risk factor for ischemic heart disease. Adiponectin as well as cytokines are useful tool in evaluation the fat tissue metabolism.The aim of the study was to evaluate the relationship between adiponectin, TNF-alpha, IL-6 and lipids in patients with TS.Patients and method: The study group consisted of 87 girls wit...

Quality life satisfaction is important for personal resources analysis and perspectives for coping with ilness.The aim of the study was to present a psychological portrait of a woman with Turner’s syndrome (TS) and assessing perspectives for increased well-being of such patients. The study concerns psychological aspects of TS women’s own assessment of their health and illness.The area of interest was:<p class="...

Women with Turner Syndrome (TS) often feel well but require detailed screening for potential sequelae, which may impact on their quality of life, morbidity and mortality. They may also have psychological issues around living with the condition. It is our opinion that women with TS benefit from attending a specialised clinic and consequently an Adult TS Clinic (ATSC) was set up, however the opinion of the women attending such a service is not known. A survey was therefore condu...

Cardiovascular disease is the major cause of mortality in women with Turner Syndrome(TS), and may be congenital or acquired. There is a high prevalence of risk factors for ischaemic heart disease(IHD) including hypertension, dyslipidaemia, diabetes and obesity. This oestrogen dose-ranging vascular physiology study compared women with TS (n=14) and 46,XX gonadal dysgenesis(GD) (n=11) to determine the relative contributions of oestrogen deficiency and genetics, and to assess the...

Cardiovascular disease is the major cause of mortality in women with Turner Syndrome(TS), and may be congenital or acquired. There is a high prevalence of risk factors for ischaemic heart disease(IHD) including hypertension, dyslipidaemia, diabetes and obesity. This oestrogen dose-ranging vascular physiology study compared women with TS (n=14) and 46,XX gonadal dysgenesis(GD) (n=11) to determine the relative contributions of oestrogen deficiency and genetics, and to assess the...

IntroductionCardiovascular complications are the main cause of increased mortality in Turner Syndrome (TS). We have previously described a high prevalence of occult aortic dysmorphology in women with TS. The aim of this study was to introduce a classification system for the variety of appearances seen by magnetic resonance imaging (MRI).Method98 women (median age 29.0, range 18.1-64.2 years) underwent MRI scanning of the aorta. MRI appearances were correlated with ...

Turner's syndrome (TS) is the commonest sex chromosome abnormality in females. It is associated with impaired glucose tolerance and hepatic dysfunction. However a medline search for primary biliary cirrhosis (PBC) and TS shows only one previously reported case (Spanish literature).A 36 year old patient was referred to the diabetes center with poorly controlled type 2 diabetes on gliclazide 80 mgs daily (HbA1C 11.2%) and elevated alkaline phosphatase (AKP...

Introduction: Turner syndrome (ST) affects 1/2500–1/4000 of female births, its association with congenital malformations is traditional, however the coexistence of hypopituitarism is exceptional. In this context, we report 6 patients; including 3 belonging to the same family and in whom the association of anterior pituitary insufficiency (IAH) to a ST was confirmed.Results: The average age of our patients was 17.2 years (11–31). The ST was sele...

Introduction: The diagnosis of Turner Syndrome (TS) must be included in the differential diagnosis of all girls with short stature. Despite overall earlier diagnosisand treatment there remain patients with TS who present late with delayed puberty.Although growth hormone (GH) is known to increase final height (FH) in girls with TS, little evidence exists on treatment in late-presenting girls.Objective and hypothesis: To assess the effect of late GH treatm...