Endocrine Abstracts

Adrenal myelolipoma is rare benign tumor composed of mature adipose cells and hematopoietic elements. Their mostly small size (<5 cm), unilateral site, and clinical quiescence is accountable for predominantly incidental disclosure. We report a case of 54-year-old man complaining of gradually aggravating pain in right hemiabdomen in whom abdominal CT revealed bilateral and giant adrenal masses composed of predominately adipose tissue with interspersed areas of solid parts d...

Septo-optic dysplasia (SOD), previously termed De Morsier’s syndrome, is a rare developmental disorder of midline brain structures characterized by optic nerve hypoplasia (ONH), midline neuroradiological abnormalities, and pituitary–hypothalamic dysfunction such as GH deficiency. The phenotype is highly variable and the clinical presentation may be mild or extremely severe. It is an infrequent disease and its causation is most presumably multifactorial, involving env...

Introduction: Pheochromocytomas are rare but treacherous catecholamine-producing tumors of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue. We refer a case with stabilization of tumor growth and hormonal improvements following repeated s.c. injections of octreotide.Case report: We report a female patient aged 35 with a finding of bilateral adrenal mass with sever cardiovascular symptomatology (f...

Testosterone has a dose-dependent stimulatory effect on erythropoiesis but the mechanism is poorly understood. Although both erythroblasts and megakaryocytes express androgen receptors, testosterone’s effect on thrombopoiesis in humans has never been studied.We report a case of 53-years-old woman presented with androgenic alopecia, hirsutism, facial redness and hoarse voice. She was a non-smoker and had a history of well-controlled diabetes mellitus...

Nearly one third of women diagnosed with invasive breast cancer are younger than 50 years with regular menstrual cycles. 60% of these tumors express estrogene and progesterone receptors. Common treatment procedure is surgery followed by chemotherapy, radiotherapy and hormone therapy. Often in younger patients chemotherapy causes permanent amenorrhoea. In case that menses afterwards occurs ovarial suppression is needed, mostly by goserelin, LH-RH agonist. The principle of thera...

Background: In March 2020, at the beginning of the first COVID-19 lockdown, Zagreb (Croatia) was hit by a strong earthquake aftermore than 100 years.Restrictive epidemiological measures affected people’s lifestyles, and the earthquakewas an additional traumatic event.Objectives: Determine whether the earthquakes and the lockdown affected glycaemic control in type 1 diabetes patients using flash glucose monitoring (FGM).Metho...

The most common cause of primary hypothyroidism is Hashimoto’s disease, while the most common cause of hyperthyroidism is Graves’ disease; both conditions are autoimmune diseases. In clinical practice, the switch from hypothyroidism to hyperthyroidism is a rare phenomenon. So far, the etiology and mechanisms of conversion have not been determined. We present a case where we believe the monoclonal antibody rituximab was the primary cause of transition. A 58-year-old m...

Intrathyroidally located parathyroid carcinoma is extremely rare cause of primary hyperparathyroidism. Multifocal papillary and follicular thyroid carcinomas are rather common.We report a case of 40-year old man presenting with substantial weight loss, anemia and multiple osteolytic lesions of both tibias. Peak serum calcium level was 5.0 mmol/l, parathyroid hormone (PTH) level was 989 pg/ml. Left thyroid lobe was firm and enlarged. Routine percutaneous ...

Introduction: The metabolic syndrome is increasingly recognized as a powerful predictor of patient risk for developing cardiovascular and cerebrovascular complications. It is viewed as the phenotypic confluence of atherogenic dyslipidaemia, hypertension, central obesity and insulin resistance (with or without type 2 diabetes) resulting from dysregulated gene expression and lifestyle behaviours.Aim: Because insulin resistance is a core defect in type 2 di...

A 74-year-old female patient was admitted to Department of Neurology due to bilateral ptosis and diplopia she suddenly felt 3 weeks prior to admission. She also complained of weakness, dizziness and swallow disability. Her medical history revealed hypertension and minor depressive disorder. Body mass index was 32 kg/m2. Electrocardiogram, chest X-ray and complete laboratory findings were normal, except elevated TSH, so levothyroxin was included in therapy. She had p...