Endocrine Abstracts

Introduction: Pheochromocytoma occasionally associates with pathological lesions of the adrenal cortex. We report a case of non-functional adrenocortical nodular hyperplasia with a concomitant pheochromocytoma in the controlateral adrenal and empty sella.Case report: We describe the case of a 52 year old women with a history of essential hypertension and type 2 diabetes mellitus. She complained of: nausea, abdominal pain, vomiting and constipation. The c...

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting 5–10% of reproductive -age female population.The aim of this study was to determine the clinical features, metabolic and hormonal profile in obese and overweight women with PCOS.Patients and method: A total of 102 women (age 31.28±6.05 and BMI 33.02±5.93) with PCOS and 110 (age 32.35±4.96 and BMI 33.05±5.87) matched controls were invest...

Endogenous hypercortisolism is a well-known immunosuppressive condition. Such endogenous cortisol secretion could suppress the clinical presentation of an ongoing autoimmune process.A 49-year-old woman was admitted in our service in august 2010 for Cushing clinical signs, arterial hypertension and hypokalemia. She had high plasma cortisol not suppressed by 1 and 8 mg dexamethasone overnight, low ACTH. Abdominal computed tomography demonstrated a tumor (3...

Aim of the study: Assessing prevalence and severity of erectile dysfunction in patients with pituitary diseases.Materials and methods: International Index of Erectile Function (IIEF) and Sexual Health Inventory for Men (SHIM) questionnaires were used to assess erectile dysfunction (ED) in 83 patients having pituitary diseases (31 patients had hypopituitarism, 11 diabetes insipidus, 10 prolactinomas, 11 nonfunctional adenomas, 16 operated acromegaly, 4 GH...

Introduction: Myxedema coma (MC) is a rare life-threatening form of hypothyroidism most often seen in patients with incompletely treated or unknown hypothyroidism exposed to stressful conditions (surgery, infections, hypothermia, trauma).Case report: We report the case of a 58-years-old woman hospitalized for coma in a peripheral hospital after a severe respiratory infection. Two days after, patient’s condition was worsening and she was transferred ...

Introduction: Body weight is positively correlated to bone mineral density. The exact mechanism is unclear but gravity may be one of the involved factors. Adipocytokines (leptin and adiponectin), secreted by the adipose tissue, are involved in bone turnover. We investigated the influence of body weight, body composition, and adipocytokines upon bone mass in pre and postmenopausal women.Design: Cross-sectional study including six groups of 8 to 16 healthy...

Introduction: Prader–Willi (PWS) is a complex genetic syndrome characterized by dysmorphic features, hypotonia, mental retardation, behavioral abnormalities, hyperphagia with progressive obesity, and endocrine dysfunctions as hypogonadism and GH deficiency. GH treatment is recommended, the major concern being aggravation of sleep apnea.Cases report: We present 2 cases with specific clinical features and genetically confirmed PWS (del 15 q11.2–q...

I fine-needle aspiration (FNA) is the gold standard in thyroid nodules management, but it is less common in the evaluation of parathyroid nodules. When imagery fails to localize a parathyroid adenoma, morphological and functional investigations, like FNA of the suspected area and scintigraphy may be useful. We present the case of a 58 years-old woman, menopaused at 47 years, who consulted for lombalgia. Vertebral DXA confirmed osteoporosis (Tscore −3.8). She was not trea...

Primary hyperparathyroidism (PHPT) is a relatively frequent problem in clinical endocrine practice. Minimally invasive parathyroid surgery is the treatment of choice but requires precise preoperatory localization. The most commonly investigation methods are ultrasonography and scintigraphy, but they are not always diagnostic. PTH assay of the aspirate from an ultrasound-guided fine-needle aspiration (USFNA) may confirm the location of pathological parathyroid tissue. The aim o...

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...