Endocrine Abstracts

A well-term baby born to consanguineous healthy Yemenese parents was observed in the hospital as parents had lost previous three babies (both male and female) within 10 days of age (in Yemen). These babies who were initially well were reported to have developed a rash and then collapsed and died. Post-mortems were not done. This baby who appeared well at birth, also developed a facial rash on day seven and was found to have hyponatremia and severe hyperkalemia, albeit a normal...

Introduction: The presence of thyroid peroxidase (TPO) antibodies in euthyroid children poses a potential risk for the development of autoimmune hypothyroidism. Little is known about the ontogeny of this process. This retrospective study aims to estimate the risk of developing hypothyroidism in euthyroid children with raised TPO antibodies and provide a guideline for follow up.Methods: Children 0–16 years with raised TPO antibodies (1996–2005) ...

A 20 years old primigravida 11weeks pregnant presented with increasing neck size, having noticed some neck swelling 4 years previously. There was no history of dysphagia or stridor. Apart of mild asthma she was well with no significant past medical or family history. TSH was normal at the time she was referred by the GP to the endocrine clinic. On examination she had a smooth thyroid swelling but no cervical lymphadenopathy. Further thyroid function tests confirmed a normal TS...

Introduction: Most children & young people (CYP) with symptoms of type 1 diabetes (T1D) tend to present to primary care. Delayed diagnosis is common and is associated with a risk of developing diabetic ketoacidosis (DKA). The prevalence of DKA at diagnosis over the last 20 years remains unchanged despite current NICE guidance and Diabetes Delivery Plans which promote prompt diagnosis of T1D. The aim of this QI initiative was to develop effective pathways to facilitate earl...

Background: Achievement of treatment targets in children and young people (CYP) with diabetes represents an important intermediary step between delivery of care and ‘hard’ outcomes such as complications. Funnel plots have been proposed as a useful tool for visualising variation in performance indicators across centers and distinguishing between common-cause (centers lying within the control limits) and special-cause variation (centers lying outside the control limits...

Case: In April 2008, a 68-year-old male was referred to the endocrine clinic with symptoms of hyperthyroidism and was prescribed carbimazole 20 mg daily. A week later, he developed sudden onset dizziness, together with reduced hearing in his left ear and associated tinnitus. Similar symptoms developed in his right ear shortly thereafter. Seven weeks after starting carbimazole, he attended the ENT outpatient clinic with severe vertigo, tinnitus and bilateral hearing loss. Otosc...

Background: Hypothyroidism occurs in 2.5% of pregnancies. We are using a database follow up system for pregnant women with hypothyroidism in our hospital. All the women with hypothyroidism are added on a database system at their first visit to the antenatal clinic. Any adjustment to thyroxine was made on the first visit after checking TFT and repeat TFTs were done at 20 and 30-weeks gestation. Any adjustments to thyroxine were communicated to them via letter. The aim of this s...

We have previously demonstrated that ERβ is necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal migration. Such early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at E18.5.Since the presence of ERβ in the embryonic brain has not been demonstrated, it remained possible that the developmental abnormalities in ERβ−/− mi...

Background: Coronavirus 2019 (Covid-19), an infectious disease caused by SARS-CoV-2 virus has been linked to autoimmunity. Graves’ disease (GD) is a common subtype of paediatric hyperthyroidism and an autoimmune condition, where antibodies stimulate the thyroid-stimulating hormone receptor on the thyroid gland to produce excess thyroid hormone. Although, paediatric GD is rare, incidence have risen before the pandemic, and this rise has accelerated since the Covid-19 pande...

Background: TE is indicated for the treatment of carcinoid syndrome diarrhea in patients with metastatic neuroendocrine tumors.Objective: To evaluate the effects of a proton pump inhibitor (OMP) and H2 antagonist (FAM) on the PK of TE and its active metabolite LP-778902 via an open-label study of OMP (40 mg orally QD × 4 days) or FAM (40 mg orally BID × 4 days) with a single 250 mg oral dose of TE. Eligible subjects: healthy, nonsmoking, aged &...