Endocrine Abstracts

Introduction: Carcinoid crisis, as an entity is poorly defined, but can be seen in patients with small bowel NET tumours after open bowel surgery or tumour unrelated procedures as cardiovascular instability (CI). Recent evidence suggests that cardiovascular instability (CI) during NET surgery is more common than previously considered.Aims and methods: We audited the incidence of CI during procedures and determined the relationship to perioperative octreo...

Introduction: There remains controversy about which patients benefit from removal of their primary small bowel tumour and whether this should be performed in a specialist tertiary referral hospital as an elective procedure. Part of the decision making and consenting process in patients with metastases will be a shared decision about surgery with the patient in light of symptoms, morbidity from surgery and survival. The aim of this study was to elucidate important institution s...

Aim: Patients with thyroid nodules, usually undergo FNA, prior to considering surgery however the results may not be conclusive. Our aim is to compare the cytology results in patients who have had two FNA’s with post-operative histology.Methods: All patients who have had thyroidectomy and two pre-operative FNA’s over 7 years were identified. Post-operative histology and FNA cytology was collected from pathology records. Standard ‘Thy’...

Aim: Pre-operative localisation of primary hyperparathyroidism (PHPT) has been based on ultrasound (US) of neck and MIBI scans with an expectation that solitary parathyroid adenomas (PA) would be localised with reasonable accuracy and sensitivity, to enable mini-parathyroidectomy. The aim of our audit was to assess the utility of both these imaging in patients with parathyroid adenoma.Method: Retrospective analysis was performed on all patients who had s...

Aim: The BTA guidelines published recently suggested an uniform U1–U5 classification of thyroid nodules on ultrasound (US) and organising management and follow-up based on these grades. The aim of our retrospective analysis was to assess the reliability and usefulness of US in assessment of thyroid nodules, in comparison with post-operative histological diagnosis.Methods: All patients who underwent thyroid surgery for thyroid nodules were assessed, ...

Background: Presently it is unknown how much of testosterone decline associated with aging is actually due to ageing per se, and how much is related to weight gain, decreased activity, and other age-related factors. Understanding the modifiable factors associated with low testosterone, such as obesity or cardiorespiratory fitness (fitness) is critical.Methods: The observational, cross-sectional study included 1653 men, ≥50 and <80 year...

Background: 25-hydroxycholecalciferol (25(OH)D) deficiency is prevalent in the Scottish paediatric population. Paediatric oncology patients are at even higher risk of becoming deficient because they spend more time indoor, often have an inadequate dietary intake and increased 25(OH)D catabolism during treatment. We aimed to assess 25(OH)D and parathyroid hormone (PTH) levels before and after supplementation in Scottish children with cancer.Methods: Plasm...

Background: Macrosomia (BW >4.5 kg) is a well-recognised complication of maternal hyperglycaemia and is associated with poor maternal and foetal outcomes. Traditional risk factors of macrosomia do not fully explain all variation as it can happen in normoglycaemia and in well-controlled diabetes. The relative contributions of these factors in different ethnicities are unknown. We investigated the predictors of BW in South Asian (SA) and White Caucasian (WC) pregnancies, and...

Background: The effects of glucocorticoids (GC) on the developing zebrafish embryo (Zfe) are poorly characterised. We have assessed the effects of pharmacological and genetic manipulation of cortisol and glucocorticoid receptors (GR) on global development and stress response during the first 120 hpf.Methods: Cortisol production was modulated by inhibiting the enzyme 11b hydroxylase using morpholino gene knockdown (MO) or incubation in the drug metyrapone...

Introduction: Stiff person syndrome (SPS) is a progressive neurological disorder characterized by fluctuating stiffness and rigidity in both axial and limb muscles. Stiff leg syndrome, an SPS variant mainly affecting limb muscles, is emerging as a distinct identity. The cause of SPS is unknown but an autoimmune pathogenesis is suspected. There are a few reported cases of hypopituitarism presenting with features suggestive of SPS.Case: A 66-year-old woman...