Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 73 PEP3.4 | DOI: 10.1530/endoabs.73.PEP3.4

ECE2021 Presented Eposters Presented ePosters 3: Pituitary and Neuroendocrinology (8 abstracts)

Benefits and harms of pituitary surgery for prolactinomas. A systematic review and meta-analysis

Marie Gry Rejkæ Sørensen 1 , Mikkel Andreassen 1 , Jakob Springborg 2 & Jesper Krogh 1


1Rigshospitalet, Department of Endocrinology, Copenhagen, Denmark; 2Rigshospitalet, Department of Neurosurgery, Copenhagen, Denmark


Objective

The objective of this systematic review was to assess the proportion of patients with prolactinomas that obtain remission or experience adverse effects after transsphenoidal surgery.

Design

A systematic review. Registered at PROSPERO, registration number CRD42020213002

Methods

A bibliographical search of PubMed and Embase was performed and last updated on September 30, 2020. Eligible studies were studies that included patients who had undergone transsphenoidal surgery for prolactinomas. A random effects analysis was used to calculate the weighted proportions.

Results

Sixty-five observational studies assessing the effect of transsphenoidal surgery for prolactinomas in 4472 patients, were included. The overall proportion of patients obtaining remission after surgery was 61% (95% CI 56 to 65; I2 = 84%), while the proportion of patients with microprolactinomas and macroprolactinomas obtaining remission was 79.8% (95% CI. 74 to 85) and 52.7% (95% CI. 44 to 61), respectively. Patient mortality was reported as 0% in 14 studies with 1413 participants. Meningitis was observed in 2.7% and postoperative CSF leakage in 4.4%.

Conclusion

This systematic review found an overall remission rate across a range of studies to be 61% (95% CI 56 to 65), and a remission rate for microprolactinomas of 79.8% (95% CI 74 to 85) after transsphenoidal surgery. There are few reported side effects and giving the improving results of transsphenoidal surgery it could be considered first line treatment in selected cases.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.