Endocrine Abstracts

Introduction: Diabetes is a serious disease that can lead to a depression of the immune system and thereby it is incriminated in serious complications of many infectious diseases among which is Covid 19. The aim of our study is to determine the virulence of SARS-COV-2 in diabetic patients.Methods: This is a transversal study conducted in the department of epidemiology at Fattouma Bourguiba Hospital in Monastir, in October 2020. The data was collected fro...

Background and aims: Dehydroepiandrosterone (DHEA) is an important prohormone and precursor of all sex steroids. DHEA fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity, which are exclusively transported in lipoproteins. In the circulation, DHEA is esterified in a reaction catalyzed by lecithin-cholesterol acyltransferase associated with HDL particles. The physiological role...

Previously we have demonstrated up-regulated expression of COX-2 and enhanced synthesis of PGE2 in cervical carcinomas. (Sales et al. 2001. J. Clin. Endocrinol Metab. 86(5):2243-2249). Enhanced PGE2 synthesis as a consequence of COX-2 overexpression has been associated with various carcinomas and is regarded as a promoter of neoplastic cell proliferation and angiogenesis. In sexually active women growth and invasiveness of neoplastic cervical cells may be...

Background and aims: Dehydroepiandrosterone fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity. DHEA-FAEs function through hydrolysis of DHEA-FAEs into free DHEA and further metabolized to biologically active steroids. The lysosomal acid lipase (LAL) mediates the intracellular hydrolysis of cholesterol esters. This study aims to study the possible role of LAL on the hydrolys...

Introduction: Homozygous familial hypercholesterolemia (HoFH) is a rare inherited autosomal dominant disease (1/20000 Individuals) involving germline mutations in the LDL metabolism pathways (LDL receptor/PCSK9/APOB/lDLRAP) that results in very high levels of LDLc, usually >10 mmol/l, and premature cardiovascular disease. The EAS guidelines recommend the use of PCSK9 inhibitors (PCSK9i) as a third line therapy in HoFH, however they report no precision regarding the effect ...

Introduction: The obstructive sleep apnea syndrome (OSAS) has a well-documented association with increase cardiovascular morbidity and mortality. The patients with OSAS have a high prevalence of hypertension and the OSAS may present similar to a pseudo-pheochromocytoma (PPH). We report two cases with PPH caused by OSAS; a common medical condition which is less recognized as a cause of raised catecholamines.Observations: Case 1: 54 year-old man had a hist...

Introduction: The association of kidney disease and diabetes mellitus is a classic feature evoking Maturity Onset Diabetes of the Young (MODY) 5 otherwise known as renal cysts and diabetes syndrome. Kidney Neoplasms are unusual feature of MODY 5. We report the case of a 45 year-old man diagnosed with kidney Neoplasm and DiabetesCase report: A 45 year-old man with a history of Diabetes Mellitus treated with lifestyle management 8 months ago, presented to ...

Introduction: Neurofibromatosis 2 (NF2) is a rare genetic disease characterized by the development of multiple schwannomas and meningiomas. It has a very variable phenotype but the most common type of tumor to develop is the vestibular schwannoma. We report clinical case of NF2 which has been revealed by hypertension.Observation: We report the case of a 25-year-old woman referred to our institution for evaluation of hypertension. She had no family histor...

Introduction: Erectile dysfunction (ED) is quite common. It poses a problem of diagnosis and management given the multiplicity of contributing factors and etiologies that can sometimes be unrecognized.Observations: We report 3 observations of patients followed for insulin-requiring diabetes. The average age was 51. They had ED for 3.5 years on overage. The clinical examination of our patients showed obesity or weight excess. The impact assessment of diab...

Introduction: Pituitary adenoma has been exceptionally reported in Down’s syndrome (DS). We report the case of a 23 year-old patient diagnosed with Down’s syndrome, who was admitted to the Endocrinology Department for a macroprolactinoma.Case report: A 23 year-old woman, diagnosed with DS, presented with acute headaches and diplopia. She had no history of trauma, and physical examination showed signs of damaged third and sixth cranial nerves, a...