Endocrine Abstracts

Introduction: Medical specialization model in Spain is carried out through specialized health training, through the residency program. Residents are a key element for the proper functioning of today’s National Health System. The aim of the study is to analyze, by an anonymous survey, the opinion of three aspects among final-year residents in Endocrinology and Nutrition (E&N): self-assessment of the knowledge acquired, working prospects, care and training consequences ...

A 36-year-old woman in follow-up due to early ovarian failure of idiopathic origin. No family history of interest. History of menarche at 12 years of age with regular menses until 18 years of age, when it begins with amenorrheic spells lasting up to 8 months. Laboratory tests revealed hypergonadotropic hypogonadism with negative ovarian autoantibodies, normal karyotype, and gynecological ultrasound showing a normal-looking uterus with slight bilateral ovarian atrophy. Negative...

Cyclophosphamide is an alkylating agent used in the treatment of malignant and autoimmune diseases. Severe hyponatraemia is a serious electrolyte disorder with life threatening neurological sequelae. We report a case of recurrent severe, symptomatic hyponatraemia that developed in a 61 year old female with systemic vasculitis and Sjogrens syndrome following low-dose cyclophosphamide.Case report: A 61 year old lady, with ANA positive systemic vasculitis p...

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

IntroductionThe pandemic has altered the day-to-day running of hospitals and most of the material and human resources have been made available for COVID-19 care. So have the residents in Endocrinology and Nutrition (MIR), who have been working on the front line, and this has led to alterations in their training programme. In addition, this unexpected and stressful work situation has had psychological consequences. The Spanish Society of Endocrinology and...

Introduction: Patients with severe cerebral Trauma are a risk population for developing hipopituytarism. Diagnosis of GHD need to study pituitary gland reserve with a stimulation test. Insulin Tolerance test (ITT) is the best standard test, although has important contraindication in these patients and its realization is not always a possible. We evaluate the diagnostic capacity of two alternative test (Glucagon Test an GHRH-GHRP6 test) and compared them with ITT.<p class="...

33-year old obese but otherwise considered ’healthy’ patient was admitted to department of surgery due to wet gangrene of left foot. Lower leg amputation was done. As patient was obese with ITM 44 kg/m2 endocrinologist was consulted. In overnight 1 mg dexamethason supression test cortisol was 72 nmol/l, HbA1c was 5.7%, TSH was 8 mIU/l, level of 25-OH D vitamin below lower range and arterial blod pressure was normal (130/80 mmHg). Patient had central obesit...

78-year old previously healthy man was reffered to Outpatient endocrinology clinic due to painful spine and shoulders. His lumbar and thoracic X-ray showed decreased lumbar and thoracic vertebrae (L1, L2 and Th 5) and densitometry indicated slightly decreased bone density with T score -1,0 in left femoral neck and L1 vertebra. Since patient mentioned recent unintentionally 10 kg weight loss he was processed to further work-up and additional blood tests were done. Secondary ost...

Most cellular actions of the steroid and thyroid hormones, vitamins A and D, and other small lipophilic molecules are mediated through binding to nuclear receptors, which act as ligand-inducible transcription factors by recruiting coactivators and corepressors. Steroid receptors bind as homodimers to hormone-response elements (HREs) in target genes, while non-steroid receptors generally bind DNA as heterodimers with the retinoid X receptor (RXR). Our understanding of nuclear r...

The identification of naturally occurring genetic mutations has provided unique insight into the current knowledge of the human hypothalamic–pituitary–gonadal axis. In the last 5 years, several loss-of-function mutations in the G-protein coupled receptor 54 (GPR54) gene have been shown to cause isolated hypogonadotropic hypogonadism. Although these mutations are not a common cause of hypogonadotropic hypogonadism, patients bearing mutations are critical to explore ge...