Endocrine Abstracts

Introduction: Waist circumference is a validated tool to measure obesity-associated cardiovascular risk factor. However it does not differentiate between superficial and visceral abdominal fat. Ultrasonography has many advantages over TC/DEXA in abdominal fat assessment, specially imaging pre-peritoneal, omental and retroperitoneal fat. Our aims were to validate the diagnostic technique and to observe correlations between different abdominal fat layers with clinical and analyt...

Introduction: The use of immunotherapy in oncology patients is increasing and is likely to continue to increase in the future. It is widely known that therapies have endocrinological side effects which can be serious, but maybe are also useful indicators to judge a response to the treatment. Presently, we do have not enough information regarding these side effects and their evolution.Materials and methods: Observational and retrospective study of 162 onc...

Background: Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR).Subjects and methods: This was a two-center, cross-sectional study in patients diagnosed with T1DM with and without DR. Su...

Introduction: Hypothyroidism is considered refractory to oral levothyroxine substitution, when there is biochemical (serum level of TSH (thyroid stimulating hormone) above the upper target level) or clinical evidence of hypothyroidism, despite increasing dosages of oral levothyroxine beyond 2.5 μg/kg daily. In these circumstances, further increments in the dosage of levothyroxine may not always be the most appropriate intervention. In such a situation, physicians need to ...

A defining trait of modern civilization is easy access to food combined with minimum energy expenditure. This unbalance is responsible for the emergence of considerable wide-spread obesity and its harrowing cortege of life-threatening complications such as type-2 diabetes. Rare genetic disorders that manifest with obesity are of great value in discovering new pieces of the jigsaw on the origins of obesity as they allow us to link a phenotype with a specific protein or group of...

Long considered as a vestige of evolution, the primary cilium has recently emerged as a crucial orgnalle in the regulation of cell function. Ciliated cells are ubiquitously present in the organism and until recently only two cellular types were considered as unciliated cells, namely the adipocyte and the hepatocyte. An in vitro approach evidenced that the preadipocyte was transiently ciliated during its terminal differentiation phase and that the primary cilium was acti...

Introduction: Alemtuzumab is a monoclonal antibody targeting the CD52 glycoprotein, which is expressed by most mature leucocytes. In early relapsing-remitting multiple sclerosis (MS) alentuzumab effectively decreases relapse rate and disability progression. However, nearly 50% of the pacients treated with alentuzumab develop secondary autoimmune disorders, being Graves’ disease the most common. The development of thyroid eye disease is unusual.Aims ...

Objective: To study the characteristics of a cohort of patients with Graves’ orbitopathy (GO) as a self-audit prior to the creation of a multidisciplinary team for the global approach of these patients.Material and Methods: Retrospective study of patients with GO treated at the Endocrinology and Ophthalmology Services of a tertiary referral hospital (Virgen Macarena University Hospital, Seville, Andalusia, Spain) between 2018 and 2021. The following...

The partum period can be seen as a transient condition of “menopause” due to the physiological decline to a baseline of the high estrogens found during pregnancy, and bone metabolism is likely to alter. Moreover, high calcium requirements for fetal growth and during breastfeeding are covered in the maternal metabolism from enhanced intestinal absorption in a Calcitriol dependent pathway, and maternal bone reabsorption under control of parathyroid hormone (PTH) parath...

We report the case of a 49 y.o male with an incidental sphenoidal-sellar tumour discovered during a cerebral CT scan during the workup of a medium to severe SARS COV 2 infection. The cerebral MRI describes an invasive tumour located in the sellar region and sphenoidal sinus – extended around the right optic nerve and into both cavernous sinuses. An emergency biopsy from the sphenoidal extension of the tumour revealed a neuroendocrine tumour. The reported diagnostic was ol...