Endocrine Abstracts

Introduction: Maternal thyroid function is put under stress during pregnancy. Thyroid disorder is very common among expectant mothers. 10% of pregnancies have subclinical hypothyroidism. Anemia, low birth weight, and neonatal mental retardation are among side effects of hypothyroidism during pregnancy.Objective: The primary and main objective is to evaluate the results for pregnant women with abnormal thyroid profiles, both for the mother and the fetus. ...

Introduction: The aetiology of a diabetic foot ulcer is multifactorial. The three principal components that ascertain the likelihood of ulceration in a diabetic foot are peripheral neuropathy, repeated minor trauma and deformity. Aims:To find the prevalence of diabetes patients having the foot at risk using the Simplified 60-Second Diabetic Foot Screen tool (SSDFST).Objectives: To find out the diabetic foot at risk.1. To ascertain the dispersal of variou...

We present the case of a 49 year old Caucasian lady who was referred for urgent evaluation to rule out Cushing’s syndrome. She had progressive increase in bulk of her shoulders and upper arms over several months. She had a history of asthma, hypertension, and alcohol excess. She had inadvertently been using fostair (steroid inhaler) as a reliever up to 10 times a day. She denied anabolic steroid or drug use. She had no clinical features of Cushing’s syndrome. There w...

In the UK, over 95% of children age 0–16 years presenting with diabetes have type 1 diabetes. Up to 25% of these present with DKA. Many present initially to GPs and it is important that children with symptoms of diabetes are referred urgently to Paediatric Diabetes Team.Aim: We carried out a survey of the current practise of GP’s when they suspect DM in a young person. The aim was to investigate whether they recognised the need for urgent refer...

Case: We present an interesting case of pituitary hypophysitis following ipilimumab therapy. A 66 year old lady previously diagnosed with left ocular melanoma in 2006 was under oncology follow up, when routine surveillance scan showed recurrence in segment six of the liver. She underwent laparoscopy and was found to have multiple liver metastases following which she was commenced on ipilimumab. Four weeks after completing her second cycle of ipilimumab, she developed severe he...

Introduction: Lifelong corticosteroid replacement is the treatment for patients with Addison’s disease. Steroid therapy need to be altered in the event of illness such as infection, accident or any other major stress. Patients need to be advised on sick day rules and this information should be reiterated at every time of patient contact.We conducted an online survey among doctors across all specialties in the Countess of Chester hospital to assess t...

A 56-year-old gentleman diagnosed with galactosemia by open liver biopsy at the age of one was referred by GP with longstanding complaints of increasing lethargy, low mood and chronic anaemia. Initial investigations revealed normocytic anemia with a normal renal function, ESR, haematinics, calcium and myeloma screen. Endocrine tests revealed anterior hypopituitarism (TSH: 4.4, FreeT4: 4.5, LH: 0.5, FSH: 2, testosterone: <0.1, prolactin: 27, IgF-1: <3.3, random cortisol...

Background: Brainstem auditory evoked potentials (BAEP) have been used for electrophysiological assessment of central neuropathy in diabetes. However, the role of this test in documenting the abnormality, the site of abnormality and relation of these abnormalities with metabolic control of diabetes are not clear as yet. The present study was done to explore the presence of abnormalities, if any, in the test parameters and relation of these with diabetic status.<p class="ab...

Introduction: Flash glucose monitoring has been widely used for people with T1DM over the last 10 years. In March 2022 NICE guidelines recommended extending use to people with T2DM on insulin, previously use was limited to people on dialysis and those self-funding.Aim: To examine the use and outcomes of flash glucose monitoring in people with T2DM.Methods: People with T2DM locally who have used flash glucose monitoring for more tha...

Turner’s syndrome (TS) results from a genetic abnormality in phenotypical female individuals where the second X chromosome is either absent or present in a mosaic form. The most obvious consequences are short stature and primary amenorrhoea, although there are often dysmorphic features as well as cardiovascular and genitourinary complications. 90% of TS patients experience primary amenorrhoea with subsequent infertility. Spontaneous recovery of ovarian function in patient...