Endocrine Abstracts

Background: Insulin resistance is proposed as a causative factor of non-alcoholic fatty liver disease (NAFLD) in the general population. Reports on NAFLD in type 1 diabetes (T1D) are increasing , but whether insulin resistance is linked to NAFLD in this population needs elucidation. Furthermore, people with T1D are an excellent model to investigate insulin resistance in relation to NAFLD without confounding by autologous insulin production.Aims and Metho...

Aristaless-related homeobox gene (ARX) mutation leads to several neurological disorders including X-linked lissencephaly with abnormal genitalia (XLAG), West syndrome and Partington syndrome, with XLAG being the most severe form. Although some of the brain pathology of XLAG has already been described, the crucial extra-brain symptoms are severe growth retardation, transient hyperglycemia and intractable diarrhea. Since ARX expresses in the islets of Langerhans du...

A 32-year-old woman with a nine-year history of right hip pain was admitted after she became unable to walk. Based on marked hypophosphatemia as indicated by serum phosphate of 1.4 mg/dl, intactPTH;29 pg/ml, TmP/GFR;1.14 mg/dl, and fibroblast growth factor 23 (FGF23) increased to 713 pg/ml, tumor-induced osteomalacia (TIO) was diagnosed. Systemic venous sampling of FGF23 performed for locating the tumor revealed an elevated level of 1600 pg/ml in the right femoral vein, and MR...

IntroductionProgressive and radioiodine-refractory thyroid cancer has poor outcomes and limited therapeutic options (i.e tyrosine kinase inhibitors) due to the transient efficacy of treatment and toxic effects. Therefore, combinatorial treatment with new therapeutic approaches are needed. Many studies link G Protein-Coupled Receptors (GPCRs) to cancer. The aim of this study is to present the first specific atlas of GPCRs expression in progressive and ref...

Goal: To carry out a retrospective analysis of case histories of children and adolescents with genetically determined types of short stature who admitted a paediatric department of a clinic of Research Institute of Endocrinologyduring 2003–2013.Materials and methods: An analysis of case histories of children and adolescents with short stature 3 to 17 years who undertook inpatient treatment in paediatric department of RIE clinic during 2003–2013...