Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep173 | Reproduction, endocrine disruptors and signalling | ECE2015

Persistent Mullerian duct syndrome: a case report

Almeida Raquel , Canha Antonio , Santos Jorge , Rocha Anabela , Dores Jorge

Persistent Mullerian duct syndrome (PMDS) is a rare disorder of sex development characterized by the persistence of Mullerian duct derivatives in a genotypic (46,XY) and phenotypic normally virilised male. PMDS is transmitted in an autosomal recessive manner, caused by mutations in the anti-Mullerian hormone gene or in the gene encoding the AMH receptor. The authors report a case of a male patient aged 62 years, with bipolar disorder, referred to the endocrinologist by inciden...

ea0035p1134 | Thyroid Cancer | ECE2014

Papillary thyroid microcarcinoma: focus on prevalence, characterization and follow-up during a 10 years time period

Pereira Maria Teresa , Carvalho Andre , Garrido Susana , Caldas Ana Rita , Freitas Claudia , Teixeira Sofia , Valente Vitor , Canha Antonio , Costa Moreira , Bateira Paulo , Borges Fatima

Introduction: Recent studies point to an ever increasing papillary thyroid microcarcinoma (PTMC) prevalence, with a percentage range between 20 and 43% of all differentiated thyroid carcinomas. It is many times considered an ‘incidental’ finding and its clinical behaviour is uncertain.Aims: To characterize a cohort of patients with PTMC, with reference to clinical and pathological variables and outcome.Methods: Data from ...

ea0081rc11.6 | Rapid Communications 11: Thyroid 2 | ECE2022

Association of thyroid hormones with clinical status and cardiovascular outcomes of HFpEF patients

Leite Ana Rita , Neves Joao Sergio , Vasques-Novoa Francisco , Saraiva Francisca A , Cristina Oliveira Ana , Borges-Canha Marta , von Hafe Madalena , Vale Catarina , Angelico-Goncalves Antonio , Leite-Moreira Adelino F

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome with high mortality, for which there are few disease modifying therapeutics. Thyroid axis dysfunction is common in heart failure (HF) and may contribute to the pathogenesis of HFpEF. However, the association of thyroid hormones (TH) with the clinical status of HFpEF patients and their prognostic impact in this syndrome are not clear. Methods: We evaluated 93 parti...

ea0090p563 | Adrenal and Cardiovascular Endocrinology | ECE2023

Influence of liver steatosis and fibrosis on cardiovascular function and prognosis of HFpEF patients

Rita Leite Ana , Borges-Canha Marta , Angelico-Goncalves Antonio , Vasques-Novoa Francisco , Saraiva Francisca , Cristina Oliveira Ana , von Hafe Madalena , Vale Catarina , Carvalho Davide , Sergio Neves Joao , Leite-Moreira Adelino F.

Introduction: Non-alcoholic fatty liver disease (NAFLD) and Heart Failure with Preserved Ejection Fraction (HFpEF) are two syndromes with increasing clinical relevance, mainly due to the rising prevalence of metabolic syndrome. Despite sharing a common metabolic background, the association between NAFLD severity and HFpEF has not yet been well explored.Aim: To evaluate the association of NAFLD steatosis and fibrosis scores with cardiovascular function an...

ea0029p1778 | Thyroid cancer | ICEECE2012

Thyroid papillary carcinoma, 30 years of experience

Costa Leite B. , Neves S. , Moreira da Costa A. , Canha A.

Papillary carcinoma is the most common histological type of thyroid cancer. The optimal treatment remains controversial, particularly with regard to the papillary microcarcinoma (≤ 10 mm).The aim of this study is the characterization of patients with this condition undergoing surgery in our hospital over a period of 30 years, evaluating treatment outcomes.Between January 1, 1980 and December 31, 2010, a total of 564 patients ...

ea0029p246 | Calcium & Vitamin D metabolism | ICEECE2012

High levels of parathormone after parathyroidectomy in primary hyperparathyroidism patients does not always mean disease recurrence…

Ferreira M. , Silva A. , Caldas A. , Dores J. , Freitas C. , Costa M. , Canha A. , Polonia J. , Vilaverde J.

Introduction: Primary hyperparathyroidism (PHPT) patients who undergo parathyroidectomy can develop isolated intact parathormone (iPTH) elevation with normal calcemia. Common causes are: renal insufficiency (RI), vitamin D deficit and hypomagnesemia.Aim: To identify clinical factors associated with iPTH elevation in patients submitted to surgery treatment.Methods: The medical records of patients admitted into Santo António&#14...

ea0081p598 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of Bariatric Surgery on the liver - An adolescent cohort

von Hafe Madalena , Chaves Joana , Neves Joao Sergio , Borges-Canha Marta , Vale Catarina , Lourenco Ines , Corujeira Susana , Campos Miguel

Introduction: Obese patients are at an increased risk of develop nonalcoholic fatty liver disease. Evidence supports that bariatric surgery might have an important impact on hepatic profile in obese adults. Literature suggests that bariatric surgery in adolescents might decrease the prevalence of some comorbidities, but information about its impact on liver profile and steatosis and fibrosis risk remains scarce.Aim: To evaluate the impact of bariatric su...

ea0081p599 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of bariatric surgery on metabolic profile − a pediatric cohort

von Hafe Madalena , Chaves Joana , Sergio Neves Joao , Borges-Canha Marta , Vale Catarina , Corujeira Susana , Campos Miguel

Introduction: Obesity is a complex multifactorial disease and its prevalence in pediatric age has increased. Obesity prejudices the individual metabolic profile due to the adipotoxicity involved in this condition. Bariatric surgery improves the weight of obese patients along with metabolic comorbidities, being today one of the most effective treatments for obesity. Time of exposure to adipotoxicity appears to be an important risk factor for the development of metabolic complic...

ea0070s4.3 | Unveiling signatures in pituitary neuroendocrine tumours | ECE2020

Unravelling the PitNET methyloma

Pico Antonio

Context: Pituitary tumorigenesis does not fit into the most common model of cancer development driven by gene mutations. Instead, epigenetic mechanisms have been widely involved. Among them, aberrant DNA methylation at CpG sites is one of epigenetic hallmarks of tumour cells. There are several methods to study the epigenetic regulation of genome activity, from DNA methylation arrays to more specific DNA methylation analysis such as pyrosequencing, Methylation-Specific PCR (MS-...