Endocrine Abstracts

Background: Survival of patients after the transplantation (Tx) of solid organs is improving. Osteoporosis and bone fractures belong to their long-term complications. The contributing factors are disturbances of bone metabolism in pre-transplant period and immunosuppressive therapy including corticosteroids after the transplantation.Patients and methods: We investigated the prevalence of osteoporosis and osteopenia in 248 diabetic patients after the Tx o...

Introduction: Hypophysitis is a rare association of inflammatory bowel disease (IBD) with only few cases reported in the literature. It can present with isolated hormone deficiencies or panhypopituitarism. Patients may also present with symptoms secondary to inflammatory pituitary mass. Management consists of hormone replacement therapy, but high dose steroids, steroid sparing agents like Rituximab or even surgery may be required for mass effect.Case rep...

Background: Immobility can be associated with severe hypercalcaemia, especially when compounded by other risk factors such as concurrent hyperthyroidism and high dietary calcium/milk intake and associated complications such as renal stones and fractures.Clinical case: 59y female presented acutely with confusion, vomiting, constipation and muscle weakness. She had history of obesity, stable Crohn’s disease with no recent increase in colonostomy outpu...

35y woman presented to haematology with normocytic anaemia and extreme fatigue. Had borderline vitamin B12, but im hydroxocobalamin did not improve Hb. A trial of iv iron was also ineffective. Bone marrow biopsy showed hypocellular bone marrow with suppressed erythropoiesis. In the absence of underlying cause, commenced prednisolone with significant improvement in Hb from 117 to 134 g/l and she felt better. Prednisolone was continued at 5 mg od. Fatigue, musculoskeletal sympto...

35y woman presented to haematology with normocytic anaemia and extreme fatigue. Had borderline vitamin B12, but im hydroxocobalamin did not improve Hb. A trial of iv iron was also ineffective. Bone marrow biopsy showed hypocellular bone marrow with suppressed erythropoiesis. In the absence of underlying cause, commenced prednisolone with significant improvement in Hb from 117 to 134 g/l and she felt better. Prednisolone was continued at 5 mg od. Fatigue, musculoskeletal sympto...

Introduction: Organ transplant recipients are at increased fracture risk compared to general population. Bone mineral density (BMD), predictive of fracture in general population, does not reflect impaired bone quality frequently present in patients with advanced organ failure. Trabecular bone score (TBS) provides surrogate measures of bone microarchitecture and therefore helps to identify persons at risk for fracture among transplant recipients.Methods: ...

Background: Langerhans cell histiocytosis (LCH) is an uncommon myeloproliferative disorder characterised by inflammatory lesions and accumulation of histiocytes leading to the destruction of affected tissues. LCH has a variable presentation and can occur as a single indolent lesion or can affect multiple organs such as the pituitary gland, bones, CNS, liver, lungs, lymph nodes, spleen, skin, heart and gastrointestinal tract. LCH of the pituitary gland most com...

Introduction: Primary hyperaldosteronism classically presents with hypertension and hypokalaemia, though many may be normokalaemic. It is most commonly caused by bilateral adrenal hyperplasia, while 30-40% have a unilateral adenoma or nodule. Aldosterone renin ratio (ARR) is performed, with confirmatory testing if required plus adrenal CT to identify an adrenal lesion. Adrenal venous sampling (AVS) distinguishes between unilateral and bilateral disease. Unilateral adrenalectom...

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder characterised by menstrual dysfunction, infertility, presence of polycystic ovaries and biochemical and clinical hyperandrogenism affecting up to 4–18% women of reproductive age. Vitamin D is thought to influence the development of PCOS through gene transcription and hormonal modulation of insulin metabolism and fertility regulation. The aim of this prospective case–control study was to...

18 year old student was referred by the Gynaecology team with primary amenorrhoea, delayed puberty, and minimum breast development. History: The patient was born by an emergency caesarean section with a birth weight of eight pounds and four ounces. She had a normal development during infancy and childhood and there was no reported developmental delay in the family. She had adrenarche at the age of ten with a normal appearance of axillary and pubic hair....