Endocrine Abstracts

Introduction: Thyroid dyshormonogenesis represents 15% of congenital hypothyroidism. It is a genetic disorder due to a trouble of Thyroid hormones synthesis. it implies many factors involved in this process mainly TPO Enzyme and NIS channel.Methods: We conducted a prospective study including 17 patients with Congenital Hypothyroidism belonging to 4 consanguine multigenerational Tunisian families. The thyroid dyshormonogenesis was diagnosed based on clini...

Introduction: Polycystic ovary syndrome is a very heterogeneous disease. Clinical and para clinical findings in such patients varies from one patient to another.Aim: The aim of our work is to study the clinical and para clinical profile of PCOS.Methods: This is a retrospective descriptive study of patients with PCOS followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia. PCOS +was diagnosed bas...

Introduction: Polycystic ovary syndrome is a pathology increasingly observed in women of childbearing age, in whom changes in hormonal and metabolic balance have been recordedAim: The aim of our work is to find Correlations between metabolic and hormonal parameters in PCOS patientsMethods: This is a retrospective descriptive and analytic study of patients with PCOS followed in the endocrinology department of Hedi Chaker University ...

IntroductionCirculating cell-free deoxyribonucleic acid (cfDNA) is a topical subject that has proven its place in oncology. However, its regular use is always compromised by the relatively high cost of the technique. The objective of our study is to determine the usefulness of cfDNA in the management of obese patients with breast cancer as well as its prognostic impact.MethodsUsing real-time multiplex polymer...

IntroductionAltered levels of circulating cell-free deoxyribonucleic acid (ccf DNA) have been found in several pathologies and might have a diagnostic value. With the steadily growing number of studies in the issues related to obesity research, it is proven, that obesity might be related to wide number of body disorders. In the current opinion, we hypothesized that there is a correlation between obesity and elevated cfDNA levels in the circulation.<p...

Introduction: COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes. The aim of our study was to assess associations between severe COVID-19 pneumonia and clinical and biological characteristics of patients with type 2 diabetes.Methods: This was a retrospective and descriptive study including 40 Tunisians patients hospital...

Ovarian carcinoma is the most deadly and leading cause of cancer death occurring in the female reproductive tracts. 17β-estradiol (E2) has long been considered as one of the effective causes of ovarian cancer through its actions via estrogen receptors (ERs). In contrast, progesterone (P4) offers protective effect against ovarian carcinogenesis. We predicted that P4 would inhibit the metastasis of BG-1 human epithelial ovarian cancer cells, which was induced by E2. In the ...

The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in prostate cancer progression. We examined that TGF-β signaling pathway is associated with ER signaling in LNCaP prostate cancer cells, which express ERα and ERβ, and ARs. We determined whether the exposure to phthalate may induce the prostate cancer ...

In the present study, we determined whether two endocrine-disrupting chemicals (EDCs), triclosan (TCS) and octylphenol (OP), are able to alter the expression of two cell cycle regulators, cyclin D1 and p21, in both in vitro and in mouse breast cancer models. In addition, we determined whether the stimulatory effects of OP or TCS on breast cancer progression may be associated with an estrogen receptor (ER)-mediated signaling pathway. Altered expressions of cyclin D1 an...

Fenhexamid is one of antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. Fenhexamid has been reported to act as an anti-androgen in an androgen receptor reporter assay in engineered human breast cancer cells. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which translocates into nucleus and dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). Although function of AR...