Endocrine Abstracts

Tributyltin (TBT) is a biocide organotin compound widely used as an antifouling in boat paints. This substance is a factor of contamination to water and food, especially marine fish. As an endocrine disruptor, TBT can interact with hormonal pathways and can induce gonadal dysfunction and glycemic dyshomeostasis; however, the effects caused by maternal exposure to TBT are scarce. Here, we investigate maternal exposure to low dose of TBT, considered safe, during pregnancy and la...

Perinatal maternal high-fat (HF) and isocaloric diet induced obesity and metabolic disorders in the offspring since weaning. At adulthood, oxidative soleus skeletal muscle of HF male offspring exhibited lipid accumulation and mitochondrial damage. At birth, HF offspring have higher n-6:n-3 polyunsaturated fatty acids (PUFA) plasma ratio. We hypothesized that HF offspring´s mitochondria of skeletal muscle exhibit damages at weaning that could be mitigated by fish oil (FO, ...

Few studies have evaluated bone histomorphometry in type 2 diabetic patients (DM2) and none has established if the disease control plays a role on bone morphology and bone marrow adipocytes. The aim of this study is to present preliminary data on bone microstructure, bone formation rate and bone marrow adipocytes in premenopausal women with DM2 with different levels of glucose control. Bone biopsy, followed by tetracycline labelling, was obtained for analysis of static and dyn...

Introduction: Pasireotide long acting release (LAR) is approved for second line treatment of acromegaly. We present 3 patients with aggressive acromegaly treated with a personalized de-escalation approach.Case 1: A 61-year-old female affected by acromegaly reisistant on first-line SSAs. In 2015 therapy was switched to pasireotide LAR 60 mg every 28 days. After two years, the IGF-I level touched the lower age range and therapy was downscaled to pasireotid...

Introduction: Hypophosphatemic rickets comprehends a group of hereditary diseases characterized by hypophosphatemia and defective bone mineralization. The most common form is X-linked, with a prevalence of 1:20.000.Objectives: Describe the follow up of patients with hypophosphatemic rickets in a public center in Brazil.Methods: Patients with hypophosphatemic rickets were selected from a database of Endocrinology and Metabolism Serv...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Background: Diabetes mellitus is mainly characterized by a dysfunction of glucose metabolism. The growth of diabetes mellitus as a chronic condition requires continuous management and requires health services to implement care strategies. Diabetes education and self-care competence have been recognized over the last few decades as essential for patients with diabetes mellitus to achieve positive treatment results.Objective: To compare self-care competenc...

Introduction: Kallmann-de Morsier Syndrome is a rare genetic disorder characterized by the combination of hypogonadotropic hypogonadism and anosmia or hyposmia. It is more prevalent in males compared to females. In this case report, we present the case of an adolescent with Kallmann-de Morsier Syndrome.Case Presentation: An 18-year-old patient was referred to our endocrinology clinic by gynecologists for the investigation of pubertal delay. The patient&#...

Introduction: Micronodular adrenocortical disease is a very rare cause of Cushing syndrome in children. This adrenocorticotropic hormone (ACTH)-independent form of Cushing syndrome is mostly a part of the Carney Complex, which is caused by mutations in the PRKAR1A gene (1). A young female with endogenous ACTH independent hypercorticism without the classical gene mutations in the pigmented and the non-pigmented form of micronodular adrenal disease is presented.<p c...