Endocrine Abstracts

Pituitary adenomas constitute the third most common intracranial neoplasm. Adenoma cells either express no hormone (null cell adenoma) or hormones of different cell lineage. About 1% of pituitary adenomas shows a plurihormonal expression pattern, which may either be attributed to one cell lineage or rarely to different cell lineages. In addition, the development of separate pituitary adenomas may be observed in 0.5–1.5% of surgical specimens and in up to 10% of autopsy ca...

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...

Background: 46, XX testicular disorder of sex development (DSD) and 11β-hydroxylase deficiency (11β-OHD) are two extremely rare types of disorder of sex development. No coexistence has been reported yet.Case Description: Here we reported the first patient diagnosed as the coexistence of 11β-OHD and 46, XX testicular DSD basing on clinical, biochemical, molecular, cytogenetic, and functional experiment findings. A 22-year-old male showed sm...

Background: Thyroid damage is known to occur during experimental iodine-induced goiter. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression. Dysregulation of specific miRNAs can interfere with tissue homeostasis. The purpose of this study was to investigate the dynamic expression profiles of miRNAs during adequate or mild-excess iodine supplementation in the iodine-deficient thyroid.Methods: Hyperplastic goiter was induced ...

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from parafollicular C-cells and accounts for 3–4% of all malignant thyroid neoplasms. MTC presents as sporadic (75–80%) or inherited tumors (20–25%). Hereditary MTC is part of multiple endocrine neoplasia type 2 (MEN2). Aim of the study was to describe clinical presentation, prognosis and therapy of sporadic MTC patients. Sixty-seven patients (pts) with histologically confirmed MTC refe...

Objectives: Lonapegsomatropin (SKYTROFA; TransCon hGH), a prodrug of somatropin, is approved by the EMA and FDA for once-weekly treatment of pediatric growth hormone deficiency (GHD). Lonapegsomatropin uses TransCon® technology, which combines a parent drug transiently linked to an inert carrier to achieve sustained release. The characterization of anti-drug antibodies (ADAs) was assessed in 3 phase 3 trials of lonapegsomatropin in pediatric GHD.Met...

Metabolic syndrome and obesity (MetS) are supposed to have a role in cancer but data analysing their association with GEP-NET are lacking. Aim of this study was to explore the association of early predictors of MetS with GEP-NET, usingas tools Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD)and Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction. A cross-sectional case-control observational study was conducted. VA...

Background: The appropriate risk stratification of patients with differentiated thyroid cancer (DTC) is crucial because most cases have an indolent behavior and need a conservative approach. One of the most widely used tools is included in the American Thyroid Association (ATA) Guidelines, based on heterogeneous literature data derived by different populations, settings, and timeframes. Recent research focused on the inclusion of other features or questioned the clinical relev...

Background and aim: Neuroendocrine neoplasms (NEN) show increasing incidence and varying biology, but epidemiological and clinical data for other than gastroenteropancreatic (GEP) and thoracic NEN are scattered. Furthermore the best therapeutic approach in NEN arising in uncommon sites is still debated. Aim of this study is to assess the epidemiological and clinical features of NEN arising in uncommon sites in a monocentric series of a referral center.Ma...

Introduction: Sporadic neuroendocrine neoplasms (NEN) occur rarely in young-adult (YA) patients, with an estimated incidence is about 2.8 cases per million, and data specific to their epidemiology are limited. The aim of our study was to better characterize the natural history, prognosis and management of NEN in YA patients (≤ 35 years old) compared to adult-elderly (AE; >35 years old).Methods: A retrospective observational study including 204 ...