Endocrine Abstracts

Aim: Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity with type 2 diabetes and a few agents such as pioglitazone and metformine has been shown to beneficial effects. SGLT-2 inhibitors are used in the treatment in type 2 diabetes (T2D). It has been shown that they can the effectivenes of improve liver function in patients with NAFLD as well as in T2D. In our study we aim to elucidate the effectiveness of SGLT-2 inhibitors as second line treatment for NAFLD pati...

Tests detecting sperm DNA fragmentation (SDF) could be included in the clinical management of male infertility. TUNEL/PI is an innovative version of the TUNEL assay, and it is able to distinguish between two different populations: PI brighter and PI dimmer sperm. The aims of the study were to determine the average value of SDF in recruited men of proven fertility and to verify whether SDF discriminates between fertile and subfertile men independently from semen quality. In add...

In recent years there has been considerable progress in identifying how insulin signals to the cell's interior. The interaction of insulin with its receptor triggers the formation of phosphatidyl inositol (3, 4, 5) trisphosphate (PIP3) at the plasma membrane which then activates several signal transduction pathways. Perhaps the most important of these is the protein kinase cascade in which 3-phosphoinositide-dependent protein kinase-1 (PDK1) activates protein kinase B (PKB, al...

Introduction: Based on cancer registries, the risk of second primary malignancies in patients with DTC increases by 30%. In our case report we aimed at understanding the patomechanism of metachronous primary tumours in patients with thyroid cancer.Case: In a 71-year old female surgery of nodular goitre (1988), followed by papillary thyroid cancer (pT3NxMx) surgery (2008) and complementary 131-I treatment (2009), were performed. In diagnostic WBS (2010) n...

Introduction: There is an increasing evidence of vitamin D role in maintaining normal glucose homeostasis. Gestational diabetes (GD) is related to insulin resistance and vitamin D deficiency has been linked with GD risk in some studies.Aims: To assess whether vitamin D levels are related with gestational diabetes in a group of healthy pregnant women.Subjects: The whole group included 845 pregnant women recruited from April 2009 to ...

Ion and fluid transport mechanisms within the eye are important for several key physiological processes including the maintenance of corneal transparency and the regulation of intraocular pressure (IOP). The mechanism involved in epithelial sodium transport in the eye is regulated by corticosteroids and at a pre-receptor level, by 11β-hydroxysteroid dehydrogenase (11β-HSD) activity. Recent studies localised type 1 (11β-HSD1), an oxo-reductase that activates cort...

Background: Obesity is one of the most critical problems nowadays, its frequency and consequences. Since the risk of morbidity and mortality increases in obese individuals, lifestyle changes, pharmacotherapy, and bariatric surgery (BS) methods are used for treatment. BS is generally considered the most effective method to treat morbid obesity. However, it is known that thyroid function has a role in weight regulation, the effect of preoperative thyroid function on weight loss ...

Retrospective study of patients with metastatic/progressive pheochromocytoma (PCC) and paraganglioma (PGL) treated with (131) I MIBG in our hospital during 2015–2018 period.Methods: There are no established criteria for establishing PCC/PGL as malignant apart from de presence of metastases at diagnosis. Radionuclide therapy (131) I-metaiodobenzylguanidine (MIBG) is frequently used in this patients when surgery is not possible. Indication of MIBG tre...

Introduction: Primary adrenocortical carcinoma (ACC) is a highly malignant but rare neoplasm. It can occur as a hormonally active or an inactive tumor. It is considered that about three-fourths of ACC cases are hormonally active, although they do not always give clinical symptoms. Mitotane (Lysodren) is registered by the FDA for the therapy of ACC, either for monotherapy or as a combined chemotherapy.Case report: A 34-year-old woman, with a histopatholog...

Introduction: Vitamin D deficiency is very common in the population, including pregnant women. There are few studies in Spain to explain their causes, so we started one in the city of Burgos, Spain (latitude 42.2° N) in April 2009 to study vitamin D status, factors that can influence and their relationship with gestational diabetes. We present preliminary data from the study on vitamin D levels.Aims: Study in pregnancy: i) vitamin levels, and ii) it...