Endocrine Abstracts

Introduction: Patients with complex health care needs and severely limited communication and mobility may be less likely to participate in research studies, and may find continued participation in such studies challenging. Allan Herndon Dudley syndrome (AHDS), due to defective thyroid hormone transporter (MCT8), causes severe neurological and physical disability. A multicentre trial (the TRIAC trial) studying the efficacy of the thyroid hormone analogue TRIAC in this rare cond...

Introduction: Adrenocortical carcinomas (ACC) are rare and frequently aggressive tumors that may be functional (hormone-secreting) – causing Cushing’s syndrome and/or virilization, or nonfunctional – presenting as an abdominal mass or as an incidental finding. We describe a rare case of stage IV adrenocortical carcinoma which first manifested as treatment resistant Cushing’s syndrome.Case report: In september of 2021, a 24-year-old fe...

Introduction: Resistance to thyroid hormones (RTH) is a rare syndrome. This condition is caused by gene mutations of thyroid hormone receptors (THR). There are two types of genes that code THR: THR alpha (THRA) and THR beta (THRB). The RTH alpha is associated with mutations in the THRA gene and is less common than RTH beta [1]. It is challenging to identify patients with RTH alpha because usually they only have mildly abnormal (or even normal) thyroid hormone levels and the se...

Introduction: Weakness is one of the most common complaints among the patients. Clinical manifestations of a hypopituitarism depend on the extent of hormone deficiency and may be non-specific and thus the diagnosis is often missed. The progressive loss of pituitary hormone secretion is usually a slow process, which can occur over a period of months or years.Clinical case: A 62 years old women who complained of mild weakness mostly in the evenings in the ...

Introduction: Follicular thyroid carcinoma (FTC) is the second most common malignancy of the thyroid gland. Distant metastasis, usually in bones or lungs, can be found in about 10%–15% of cases. A clinical case of FTC distant bone metastasis is presented.Case: A 62-year-old male came to endocrinologist for annual follow-up (FU) of multinodular goiter, euthyreosis in 2010. Two years before prostate carcinoma (T1N0M0) was also diagnosed for the patien...

Introduction: Ectopic benign thyroid tissue outside the normal migration path of the thyroid is an extremely rare condition that, to our knowledge, has never been described in the orbit.Clinical case: 75-year-old woman with nodular thyroid was referred to Vilnius University Hospital Santariskiu Klinikos for fine needle aspiration biopsy. Her complaints were palpitations, difficulty swallowing, diplopia, exophthalmos with medial and –superio...

Introduction: Insulinoma is a rare pancreatic tumor, typically sporadic, solitary and benign. However, nonspecific symptoms of hypoglycemia, negative laboratory investigations and small size of these tumors can retard the diagnosis, and symptoms may be misattributed to psychiatric, cardiac, neurological disorders.Case presentation: A 35-year-old male had history of night time seizures with hallucinations, delirium and spasms, lasting from 10 minutes to 1...

Hashimoto encephalopathy (HE) is a rare and steroid responsive encephalopathy associated with autoimmune thyroiditis (1). Patients with Hashimoto encephalopathy may present with a variety of neuropsychiatric signs (2). 68-year old woman was admitted to the Neurology Department, of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK), due to disorder of consciousness of uncertain aetiology in August 2016. The signs of motor dysfunction, generalized ri...

Aim: The aim of the study was to evaluate sE-selectin and Endothelin-1 as markers of endothelial function and autonomic tone at early stages of impaired glucose tolerance and in metabolic syndrome (MetS).Material and methods: A total of 87 subjects - 48 females and 39 males (mean age 45.7±11.6 years, mean BMI 31.4±6.6 kg/m2), divided into three groups according to glucose tolerance: 35 with normal glucose tolerance (NGT), 35 with pre...

Introduction: Familial dysalbuminemic hyperthyroxinemia (FDH) is characterized by artefactual hyperthyroxinemia caused by enhanced binding affinity of thyroxine to the mutant albumin. However little is known about how FDH affects the measurement of thyroid hormones, especially FT3, across many assay platforms.Methods: Forty-eight genetically confirmed FDH patients (R218H mutation) had FT4 and FT3 measured with 1-step (ADVIA CENTAUR®, Siem...